Literature summary for 4.1.99.13 extracted from

Glas, A.; Kaya, E.; Schneider, S.; Heil, K.; Fazio, D.; Maul, M.; Carell, T.
DNA (6-4) photolyases reduce dewar isomers for isomerization into (6-4) lesions (2010), J. Am. Chem. Soc., 132, 3254-3255.

Search for more literature for 4.1.99.13

Crystallization (Commentary)

Crystallization (Comment)	Organism
to study how the enzyme recognizes the T(6-4)C and T(Dew)C lesion analogues in the active site, DNA duplexes are crystallized together with the (6-4) photolyase	Drosophila melanogaster

Protein Variants

Protein Variants	Comment	Organism
H365N	mutant shows no repair activity	Drosophila melanogaster

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	Q8SXK5	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
(6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA)	repair of Dewar valence isomers by (6-4) photolyases involves the rearrangement of the Dewar lesions into the corresponding (6-4) lesions. This reaction requires electron injection. (6-4) photolyases have two catalytic functions: Splitting (6-4) lesions and catalyzing the formal 4pi sigmatropic rearrangement of Dewar isomers to (6-4) lesions	Drosophila melanogaster	a

Synonyms

Synonyms	Comment	Organism
(6-4) photolyase	-	Drosophila melanogaster

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Drosophila melanogaster

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)