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Literature summary for 4.1.99.13 extracted from

  • Yamamoto, J.; Hitomi, K.; Hayashi, R.; Getzoff, E.D.; Iwai, S.
    Role of the carbonyl group of the (6-4) photoproduct in the (6-4) photolyase reaction (2009), Biochemistry, 48, 9306-9312.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Xenopus laevis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information imine analogue of the (6-4) photoproduct (T(6-4)TNH2), in which the carbonyl group is replaced with an iminium cation, is not repaired by the (6-4) photolyase, even in the presence of a 10fold molar excess of the enzyme, although the enzyme binds to the oligonucleotide with considerable affinity. Carbonyl group of the 3' pyrimidone ring plays an important role in the (6-4) photolyase reaction Xenopus laevis ?
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Synonyms

Synonyms Comment Organism
(6-4) photolyase
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Xenopus laevis