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Literature summary for 4.1.99.1 extracted from
- The influence of selected O-alkyl derivatives of cyclodextrins on the enzymatic decomposition of l-tryptophan by l-tryptophan indole-lyase (2008), Carbohydr. Res., 344, 304-130.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2,3-di-O-methyl)-alpha-cyclodextrin | - |
Escherichia coli |  |
| (2,3-di-O-methyl)-beta-cyclodextrin | - |
Escherichia coli | |
| (2-hydroxypropyl)-alpha-cyclodextrin | - |
Escherichia coli | |
| (2-hydroxypropyl)-beta-cyclodextrin | - |
Escherichia coli | |
| additional information | cyclodextrin derivatives cause the inhibition of enzymatic process, both competitive and non-competitive. The competitive inhibition is connected with the formation of inclusion complexes between cyclodextrins and L-tryptophan, related to the geometry of these complexes. The mechanism of the non-competitive inhibition is not so evident | Escherichia coli | |
| [2,3,6-tri-O-(2'-methoxyethyl)]-alpha-cyclodextrin | - |
Escherichia coli | |
| [2,3-di-O-(2'-methoxyethyl)]-alpha-cyclodextrin | - |
Escherichia coli | |
| [2,3-di-O-(2'-methoxyethyl)]-beta-cyclodextrin | - |
Escherichia coli | |
| [2,3-di-O-methyl-6-O-(2'-methoxyethyl)]-alpha-cyclodextrin | - |
Escherichia coli | |
| [2,3-di-O-methyl-6-O-(2'-methoxyethyl)]-beta-cyclodextrin | - |
Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.347 | - |
L-tryptophan | - |
Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + H2O | - |
Escherichia coli | indole + pyruvate + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| L-tryptophan indole-lyase | - |
Escherichia coli |
| Tpase | - |
Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Escherichia coli | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.24 | - |
[2,3,6-tri-O-(2'-methoxyethyl)]-alpha-cyclodextrin | - |
Escherichia coli | |
| 0.52 | - |
[2,3-di-O-methyl-6-O-(2'-methoxyethyl)]-alpha-cyclodextrin | - |
Escherichia coli | |
| 0.68 | - |
[2,3-di-O-(2'-methoxyethyl)]-beta-cyclodextrin | - |
Escherichia coli | |
| 1.36 | - |
[2,3-di-O-methyl-6-O-(2'-methoxyethyl)]-beta-cyclodextrin | - |
Escherichia coli | |
| 2.15 | - |
[2,3-di-O-(2'-methoxyethyl)]-alpha-cyclodextrin | - |
Escherichia coli | |
| 2.97 | - |
(2-hydroxypropyl)-beta-cyclodextrin | - |
Escherichia coli | |
| 4.77 | - |
(2,3-di-O-methyl)-alpha-cyclodextrin | - |
Escherichia coli | |
| 4.97 | - |
(2-hydroxypropyl)-alpha-cyclodextrin | - |
Escherichia coli | |
| 11.94 | - |
(2,3-di-O-methyl)-beta-cyclodextrin | - |
Escherichia coli | |
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