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Literature summary for 4.1.99.1 extracted from

  • Kiick, D.M.; Phillips, R.S.
    Mechanistic deductions from multiple kinetic and solvent deuterium isotope effects and pH studies of pyridoxal phosphate dependent carbon-carbon lyases: Escherichia coli tryptophan indole-lyase (1988), Biochemistry, 27, 7339-7344.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Ala competitive Escherichia coli
oxindolyl-L-Ala competitive Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
L-tryptophan + H2O = indole + pyruvate + NH3 mechanism that requires two catalytic bases Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Trp + H2O
-
Escherichia coli indole + pyruvate + NH4+
-
?
S-methyl-L-Cys + H2O
-
Escherichia coli ?
-
?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent on Escherichia coli