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Literature summary for 4.1.3.44 extracted from
- Mechanistic studies of the radical S-adenosyl-L-methionine enzyme 4-demethylwyosine synthase reveal the site of hydrogen atom abstraction (2015), Biochemistry, 54, 3569-3572 .
No PubMed abstract available
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine | Methanocaldococcus jannaschii | - |
4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O | - |
ir |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Methanocaldococcus jannaschii | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ammonium sulfate precipitation, HiTrap chealting column chromatography, and butyl Sepharose column chromatography | Methanocaldococcus jannaschii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine | - |
Methanocaldococcus jannaschii | 4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 4-demethylwyosine synthase | - |
Methanocaldococcus jannaschii |
| TYW1 | - |
Methanocaldococcus jannaschii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| S-adenosyl-L-methionine | - |
Methanocaldococcus jannaschii | |
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Release 2023.1 (January 2023)
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