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Literature summary for 4.1.3.44 extracted from

  • Noma, A.; Kirino, Y.; Ikeuchi, Y.; Suzuki, T.
    Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA (2006), EMBO J., 25, 2142-2154.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.3.44

Protein Variants

Protein Variants Comment Organism
C479A mutation in the conserved C479xxxC483xxC486 motif of the radical-Ado-Met domain, complete loss of activity Saccharomyces cerevisiae
C483A mutation in the conserved C479xxxC483xxC486 motif of the radical-Ado-Met domain, complete loss of activity Saccharomyces cerevisiae
C486A mutation in the conserved C479xxxC483xxC486 motif of the radical-Ado-Met domain, complete loss of activity Saccharomyces cerevisiae
E532A mutation in a candidate GGE motif in the radical Ado-Met domain, no loss of activity Saccharomyces cerevisiae
E550A mutation in a candidate GGE motif in the radical Ado-Met domain, complete loss of activity Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae Q08960
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Saccharomyces cerevisiae ATCC 204508 Q08960
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Synonyms

Synonyms Comment Organism
TYW1
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 Saccharomyces cerevisiae
YPL207W locus name Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
[4Fe-4S]-center
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function genes YPL207w, YML005w, YGL050w and YOL141w, named TYW1, TYW2, TYW3 and TYW4, respectively are essential for wybutosine synthesis. TYW1 is an iron-sulfur (Fe-S) cluster protein responsible for the tricyclic formation Saccharomyces cerevisiae