Literature summary for 4.1.3.4 extracted from

Leipnitz, G.; Seminotti, B.; Fernandes, C.G.; Amaral, A.U.; Beskow, A.P.; da Silva, L.d.e..B.; Zanatta, A.; Ribeiro, C.A.; Vargas, C.R.; Wajner, M.
Striatum is more vulnerable to oxidative damage induced by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as compared to liver (2009), Int. J. Dev. Neurosci., 27, 351-356.

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Application

Application	Comment	Organism
medicine	3-hydroxy-3-methylglutaric aciduria is an autosomal recessive branched chain organic aciduria caused by the deficiency of the enzyme 3-hydroxy-3-methylglutaryl-CoA lyase	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(S)-3-Hydroxy-3-methylglutaryl-CoA	Rattus norvegicus	-	Acetyl-CoA + acetoacetate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-3-Hydroxy-3-methylglutaryl-CoA	-	Rattus norvegicus	Acetyl-CoA + acetoacetate	-	?

Synonyms

Synonyms	Comment	Organism
3-Hydroxy-3-methylglutaryl-CoA lyase	-	Rattus norvegicus

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Release 2023.1 (January 2023)