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Literature summary for 4.1.3.38 extracted from

  • Zhang, Y.; Bai, L.; Deng, Z.
    Functional characterization of the first two actinomycete 4-amino-4-deoxychorismate lyase genes (2009), Microbiology, 155, 2450-2459.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Streptomyces sp.

Protein Variants

Protein Variants Comment Organism
additional information a mutant with pabC-1 inactivated still retains about 20% of the wild type level of antibiotic FR-008 production, pabC-1/pabC-2 double mutation severely reduces antibiotic FR-008 production and renders the mutant p-aminobenzoic acid-auxotrophic Streptomyces sp.
additional information pabC-1/pabC-2 double mutation severely reduces antibiotic FR-008 production and renders the mutant p-aminobenzoic acid-auxotrophic Streptomyces sp.

Organism

Organism UniProt Comment Textmining
Streptomyces sp.
-
-
-
Streptomyces sp. B8Y8J0 PabC-2
-
Streptomyces sp. FR-008
-
-
-
Streptomyces sp. FR-008 B8Y8J0 PabC-2
-

Purification (Commentary)

Purification (Comment) Organism
nickel affinity column chromatography Streptomyces sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-amino-4-deoxychorismate
-
Streptomyces sp. 4-aminobenzoate + pyruvate
-
?
4-amino-4-deoxychorismate
-
Streptomyces sp. FR-008 4-aminobenzoate + pyruvate
-
?

Synonyms

Synonyms Comment Organism
4-amino-4-deoxychorismate lyase
-
Streptomyces sp.
ADC lyase
-
Streptomyces sp.
PabC-1
-
Streptomyces sp.
PabC-2
-
Streptomyces sp.

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Streptomyces sp.