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Literature summary for 4.1.3.27 extracted from

  • Man, H.; Pollmann, S.; Weiler, E.W.; Kirby, E.G.
    Increased glutamine in leaves of poplar transgenic with pine GS1a caused greater anthranilate synthetase alpha-subunit (ASA1) transcript and protein abundances: an auxin-related mechanism for enhanced growth in GS transgenics? (2011), J. Exp. Bot., 62, 4423-4431.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
quantitative real-time PCR enzyme expression analysis Nicotiana tabacum
quantitative real-time PCR enzyme expression analysis Populus tremula x Populus alba

Protein Variants

Protein Variants Comment Organism
additional information leaves of transgenic poplar with ectopic expression of the pine cytosolic glutamine synthetase, GS1a, EC 6.3.1.2, produce significantly more glutamine and significantly enhanced ASA alpha-subunit (ASA1) transcript and protein, approximately 130% and 120% higher than in the untransformed controls, respectively. L-Glutamate, tryptophan, and 4-aminobutanoate are also significantly enhanced in the GS1a transgenic poplars Populus tremula x Populus alba
additional information tobacco leaves fed with 30 mM glutamine and 2 mM chorismate produce significantly enhanced ASA alpha-subunit (ASA1) transcript and protein, approximately 175% and 90% higher than in the untransformed controls, respectively Nicotiana tabacum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
chorismate + L-glutamine Nicotiana tabacum
-
 anthranilate + pyruvate + L-glutamate
-
 ?
chorismate + L-glutamine Populus tremula x Populus alba
-
 anthranilate + pyruvate + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Nicotiana tabacum
-
-
-
Populus tremula x Populus alba
-
 hybrid, clone INRA 7171-B4
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Nicotiana tabacum
-
leaf
-
 Populus tremula x Populus alba
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chorismate + L-glutamine
-
 Nicotiana tabacum anthranilate + pyruvate + L-glutamate
-
 ?
chorismate + L-glutamine
-
 Populus tremula x Populus alba anthranilate + pyruvate + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
ASA
-
 Nicotiana tabacum
ASA
-
 Populus tremula x Populus alba

Expression

Organism Comment Expression
Nicotiana tabacum L-glutamine induces the enzyme transcription and translation through the regulation of auxin biosynthesis up
Populus tremula x Populus alba L-glutamine induces the enzyme transcription and translation through the regulation of auxin biosynthesis up

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the initial step in the pathway for both tryptophan-dependent and tryptophan-independent pathways in the biosynthesis of indole-3-acetic acid, the transfer of the alpha-amino group of glutamine to chorismate producing anthranilate Nicotiana tabacum
metabolism the enzyme catalyzes the initial step in the pathway for both tryptophan-dependent and tryptophan-independent pathways in the biosynthesis of indole-3-acetic acid, the transfer of the alpha-amino group of glutamine to chorismate producing anthranilate Populus tremula x Populus alba
physiological function enhanced cellular glutamine may account for the enhanced growth in glutamine synthase-expressing transgenic poplar plants through the regulation of auxin biosynthesis Populus tremula x Populus alba