Cloned (Comment) | Organism |
---|---|
mutant anthanilate synthase Pro21Ser that is insensitive to feedback inhibition by Trp | Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
P21S | insensitive to feedback inhibition by Trp | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-Trp | strain with a anthanilate synthase that is insensitive to feedback inhibition by Trp, the 61st nucleotide, C to A substitution, that changes Pro21 to Ser is the cause of the desensitization to feedback inhibition by Trp | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Escherichia coli | first enzyme in the branch pathway in Trp biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Corynebacterium glutamicum | - |
- |
- |
Escherichia coli | - |
strain with a mutant anthranilate synthase Pro21Gln that is insensitive to feedback inhibition by Trp | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
chorismate + L-Gln | - |
Escherichia coli | anthranilate + pyruvate + L-glutamate | - |
? | |
chorismate + L-Gln | - |
Corynebacterium glutamicum | anthranilate + pyruvate + L-glutamate | - |
? | |
additional information | first enzyme in the branch pathway in Trp biosynthesis | Escherichia coli | ? | - |
? |