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Literature summary for 4.1.3.1 extracted from

  • Chung, J.C.; Rzhepishevska, O.; Ramstedt, M.; Welch, M.
    Type III secretion system expression in oxygen-limited Pseudomonas aeruginosa cultures is stimulated by isocitrate lyase activity (2013), Open biology, 3, 120131.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
3-nitropropionic acid
-
Pseudomonas aeruginosa
Itaconic acid
-
Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate Pseudomonas aeruginosa
-
succinate + glyoxylate
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
gene aceA
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information high enzyme expression in cystic fibrosis samples Pseudomonas aeruginosa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate
-
Pseudomonas aeruginosa succinate + glyoxylate
-
?

Synonyms

Synonyms Comment Organism
AceA
-
Pseudomonas aeruginosa
ICL
-
Pseudomonas aeruginosa

General Information

General Information Comment Organism
malfunction an aceA mutant displays enhanced biofilm formation during anaerobic growth. Expression of PcrV, of PopN (a regulator of the T3SS translocation process), ExoS (a T3 effector protein), and ExsD (a T3S regulator) is greatly reduced in the aceA mutant. Expression of aceA from a plasmid in trans can restore PcrV expression and ICL activity in the aceA mutant Pseudomonas aeruginosa
metabolism the enzyme is important in the glyoxylate shunt pathway, which is strongly induced in Pseudomonas aeruginosa during anaerobic growth and during growth on C2-sources, such as acetate or fatty acids, as the sole carbon source, overview Pseudomonas aeruginosa
physiological function the enzyme regulates the type III secretion system, T3SS, overview. Expression of the T3SS in oxygen-limited growth conditions is strongly dependent on the glyoxylate shunt enzyme, isocitrate lyase, which probably affects the RetS/LadS signalling pathways. ICL-dependent regulation of the T3SS does not alter the expression level of the master transcriptional regulator, ExsA, but affects expression of the T3 structural proteins, effectors and regulators, ExsC, ExsD and ExsE Pseudomonas aeruginosa