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Literature summary for 4.1.3.1 extracted from

  • Chung, S.C.; Jang, K.H.; Park, J.; Ahn, C.H.; Shin, J.; Oh, K.B.
    Sargachromanols as inhibitors of Na+/K+ ATPase and isocitrate lyase (2011), Bioorg. Med. Chem. Lett., 21, 1958-1961.
    View publication on PubMed
Search for more literature for 4.1.3.1

Cloned(Commentary)

Cloned (Comment) Organism
-
 Candida albicans

Inhibitors

Inhibitors Comment Organism Structure
(2E,6E)-9-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-2,6-dimethylnona-2,6-dienal
-
 Candida albicans
(2E,7E)-10-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-3,7-dimethyl-2-(2-methylprop-1-en-1-yl)deca-2,7-dienal
-
 Candida albicans
(2R)-2-[(3E,7E)-9-(hydroxymethyl)-4,8,11-trimethyldodeca-3,7,10-trien-1-yl]-2,8-dimethyl-3,4-dihydro-2H-chromen-6-ol
-
 Candida albicans
(4R,5R)-4-[(2E)-5-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-2-methylpent-2-en-1-yl]-2-methyl-5-(2-methylprop-1-en-1-yl)cyclopent-2-en-1-one
-
 Candida albicans
3-nitropropionate
-
 Candida albicans

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Candida albicans ATCC 10231
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Candida albicans

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
isocitrate lyase
-
 Candida albicans

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0348
-
 pH 7.0, 37°C Candida albicans 3-nitropropionate
0.1184
-
 pH 7.0, 37°C Candida albicans (2R)-2-[(3E,7E)-9-(hydroxymethyl)-4,8,11-trimethyldodeca-3,7,10-trien-1-yl]-2,8-dimethyl-3,4-dihydro-2H-chromen-6-ol
0.141
-
 pH 7.0, 37°C Candida albicans (4R,5R)-4-[(2E)-5-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-2-methylpent-2-en-1-yl]-2-methyl-5-(2-methylprop-1-en-1-yl)cyclopent-2-en-1-one
0.1729
-
 pH 7.0, 37°C Candida albicans (2E,7E)-10-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-3,7-dimethyl-2-(2-methylprop-1-en-1-yl)deca-2,7-dienal
0.185
-
 pH 7.0, 37°C Candida albicans (2E,6E)-9-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-2,6-dimethylnona-2,6-dienal