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Literature summary for 4.1.3.1 extracted from
- Escherichia coli isocitrate lyase: properties and comparisons (1988), Biochim. Biophys. Acta, 966, 30-35.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-nitropropionate | 50% inhibition at 0.04 mM | Escherichia coli |  |
| Ca2+ | - |
Escherichia coli | |
| Dithionitrobenzoate | - |
Escherichia coli | |
| glycolate | 50% inhibition at 5 mM | Escherichia coli | |
| HgCl2 | 100% inhibition at 0.01 mM | Escherichia coli | |
| Hydroxymalonate | 50% inhibition at 0.5 mM | Escherichia coli | |
| KCl | - |
Escherichia coli | |
| malonate | - |
Escherichia coli | |
| methylmalonate | 50% inhibition at 15 mM | Escherichia coli | |
| NaCl | - |
Escherichia coli | |
| oxalate | - |
Escherichia coli | |
| succinate | - |
Escherichia coli | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | no activity in absence of exogenous cation | Escherichia coli | |
| Co2+ | Co2+ 17% as effective as Mg2+ | Escherichia coli | |
| Mg2+ | no activity in absence of exogenous cation, Mg2+ most effective | Escherichia coli | |
| Mn2+ | no activity in absence of exogenous cation | Escherichia coli | |
| Mn2+ | Mn2+ 54% as effective as Mg2+ | Escherichia coli | |
| Ni2+ | no activity in absence of exogenous cation, Ni2+ 7% as effective as Mg2+ | Escherichia coli | |
| Sr2+ | no activity in absence of exogenous cation, Sr2+ 3% as effective as Mg2+ | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isocitrate | Escherichia coli | glyoxylate cycle | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isocitrate | - |
Escherichia coli | succinate + glyoxylate | - |
r | |
| isocitrate | glyoxylate cycle | Escherichia coli | ? | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
3-nitropropionate | - |
Escherichia coli | |
| 0.5 | - |
Hydroxymalonate | - |
Escherichia coli | |
| 15 | - |
methylmalonate | - |
Escherichia coli | |
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