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Literature summary for 4.1.2.60 extracted from

  • Pribat, A.; Jeanguenin, L.; Lara-Nunez, A.; Ziemak, M.J.; Hyde, J.E.; de Crecy-Lagard, V.; Hanson, A.D.
    6-pyruvoyltetrahydropterin synthase paralogs replace the folate synthesis enzyme dihydroneopterin aldolase in diverse bacteria (2009), J. Bacteriol., 191, 4158-4165 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.2.60

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli DH5alpha cells Plasmodium falciparum
expressed in Escherichia coli DH5alpha cells Thermotoga maritima
expressed in Escherichia coli DH5alpha cells Clostridium botulinum
expressed in Escherichia coli DH5alpha cells Syntrophus aciditrophicus
expressed in Escherichia coli DH5alpha cells Leptospira interrogans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7,8-dihydroneopterin 3'-triphosphate Plasmodium falciparum
-
 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate
-
 ?
7,8-dihydroneopterin 3'-triphosphate Thermotoga maritima
-
 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate
-
 ?
7,8-dihydroneopterin 3'-triphosphate Clostridium botulinum
-
 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate
-
 ?
7,8-dihydroneopterin 3'-triphosphate Syntrophus aciditrophicus
-
 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate
-
 ?
7,8-dihydroneopterin 3'-triphosphate Leptospira interrogans
-
 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate
-
 ?
7,8-dihydroneopterin 3'-triphosphate Leptospira interrogans L1-130
-
 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
-
-
-
Leptospira interrogans
-
-
-
Leptospira interrogans L1-130
-
-
-
Plasmodium falciparum
-
-
-
Syntrophus aciditrophicus
-
-
-
Thermotoga maritima
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7,8-dihydroneopterin 3'-triphosphate
-
 Plasmodium falciparum 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate
-
 ?
7,8-dihydroneopterin 3'-triphosphate
-
 Thermotoga maritima 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate
-
 ?
7,8-dihydroneopterin 3'-triphosphate
-
 Clostridium botulinum 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate
-
 ?
7,8-dihydroneopterin 3'-triphosphate
-
 Syntrophus aciditrophicus 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate
-
 ?
7,8-dihydroneopterin 3'-triphosphate
-
 Leptospira interrogans 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate
-
 ?
7,8-dihydroneopterin 3'-triphosphate
-
 Leptospira interrogans L1-130 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate
-
 ?
additional information the enzyme does not exhibit significant dihydroneopterin aldolase activity Plasmodium falciparum ?
-
 ?
additional information the enzyme does not exhibit significant dihydroneopterin aldolase activity Thermotoga maritima ?
-
 ?
additional information the enzyme does not exhibit significant dihydroneopterin aldolase activity Clostridium botulinum ?
-
 ?
additional information the enzyme does not exhibit significant dihydroneopterin aldolase activity Syntrophus aciditrophicus ?
-
 ?
additional information the enzyme does not exhibit significant dihydroneopterin aldolase activity Leptospira interrogans ?
-
 ?
additional information the enzyme does not exhibit significant dihydroneopterin aldolase activity Leptospira interrogans L1-130 ?
-
 ?

Synonyms

Synonyms Comment Organism
PTPS-III
-
 Plasmodium falciparum
PTPS-III
-
 Thermotoga maritima
PTPS-III
-
 Clostridium botulinum
PTPS-III
-
 Syntrophus aciditrophicus
PTPS-III
-
 Leptospira interrogans