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Literature summary for 4.1.2.53 extracted from

  • Hernandez, K.; Joglar, J.; Bujons, J.; Parella, T.; Clapes, P.
    Nucleophile promiscuity of engineered class II pyruvate aldolase YfaU from E. coli (2018), Angew. Chem. Int. Ed. Engl., 57, 3583-3587 .
    View publication on PubMed
Search for more literature for 4.1.2.53

Protein Variants

Protein Variants Comment Organism
L216A the mutant shows a high efficiency in the aldol additions of pyruvate Escherichia coli
W23A/L216A the mutant shows a high efficiency in the aldol additions of pyruvate Escherichia coli
W23V the mutant shows a high efficiency in the aldol additions of pyruvate Escherichia coli
W23V/F174V/L216A the mutant shows a high efficiency in the aldol additions of pyruvate Escherichia coli
W23V/L216A the mutant shows a high efficiency in the aldol additions of pyruvate Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + (S)-lactaldehyde Escherichia coli
-
 2-dehydro-3-deoxy-L-rhamnonate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P76469
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxobutanoate + benzyl (2R)-2-formylpyrrolidine-1-carboxylate 50% conversion Escherichia coli ?
-
 ?
2-oxobutanoate + benzyl (2S)-2-formylpyrrolidine-1-carboxylate 71% conversion Escherichia coli ?
-
 ?
2-oxobutanoate + benzyl [(2R)-1-oxopropan-2-yl]carbamate 73-88% conversion Escherichia coli ?
-
 ?
2-oxobutanoate + benzyl [(2S)-1-oxopropan-2-yl]carbamate 70-94% conversion Escherichia coli ?
-
 ?
2-oxooctanoate + benzyl [(2R)-1-oxopropan-2-yl]carbamate 40% conversion Escherichia coli ?
-
 ?
2-oxooctanoate + benzyl [(2S)-1-oxopropan-2-yl]carbamate 30% conversion Escherichia coli ?
-
 ?
2-oxopentanoate + benzyl (2R)-2-formylpyrrolidine-1-carboxylate 40% conversion Escherichia coli ?
-
 ?
2-oxopentanoate + benzyl (2S)-2-formylpyrrolidine-1-carboxylate 45% conversion Escherichia coli ?
-
 ?
2-oxopentanoate + benzyl [(2R)-1-oxopropan-2-yl]carbamate 95% conversion Escherichia coli ?
-
 ?
2-oxopentanoate + benzyl [(2S)-1-oxopropan-2-yl]carbamate 91% conversion Escherichia coli ?
-
 ?
4-(methylsulfanyl)-2-oxobutanoate + benzyl [(2R)-1-oxopropan-2-yl]carbamate 91% conversion Escherichia coli ?
-
 ?
4-(methylsulfanyl)-2-oxobutanoate + benzyl [(2S)-1-oxopropan-2-yl]carbamate 75% conversion Escherichia coli ?
-
 ?
4-methyl-2-oxopentanoate + benzyl [(2R)-1-oxopropan-2-yl]carbamate 52% conversion Escherichia coli ?
-
 ?
4-methyl-2-oxopentanoate + benzyl [(2S)-1-oxopropan-2-yl]carbamate 50% conversion Escherichia coli ?
-
 ?
pyruvate + (S)-lactaldehyde
-
 Escherichia coli 2-dehydro-3-deoxy-L-rhamnonate
-
 ?

Synonyms

Synonyms Comment Organism
2-dehydro-3-deoxyrhamnonate aldolase
-
 Escherichia coli
YfaU
-
 Escherichia coli