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Literature summary for 4.1.2.49 extracted from
- Purification and characterization of L-allo-threonine aldolase from Aeromonas jandaei DK-39 (1997), FEMS Microbiol. Lett., 151, 245-248.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-chloromercuribenzoate | 1 mM, 76% inhibition | Aeromonas jandaei |  |
| 5,5'-dithiobis(2-nitrobenzoic acid) | 1 mM, 100% inhibition | Aeromonas jandaei | |
| Acriflavine | 1 mM, 65% inhibition | Aeromonas jandaei | |
| Ag2SO4 | 1 mM, 100% inhibition | Aeromonas jandaei | |
| AlCl3 | 1 mM, 69% inhibition | Aeromonas jandaei | |
| CdCl2 | 1 mM, 80% inhibition | Aeromonas jandaei | |
| D-(-)-penicillamine | 1 mM, 87% inhibition | Aeromonas jandaei | |
| FeCl3 | 1 mM, 100% inhibition | Aeromonas jandaei | |
| FeSO4 | 1 mM, 100% inhibition | Aeromonas jandaei | |
| HgCl2 | 1 mM, 99% inhibition | Aeromonas jandaei | |
| hydroxylamine | 1 mM, 100% inhibition | Aeromonas jandaei | |
| iodoacetamide | 1 mM, 56% inhibition | Aeromonas jandaei | |
| N-bromosuccinimide | 1 mM, 89% inhibition | Aeromonas jandaei | |
| phenylhydrazine | 1 mM, 91% inhibition | Aeromonas jandaei | |
| Semicarbazide | 1 mM, 63% inhibition | Aeromonas jandaei | |
| ZnSO4 | 1 mM, 98% inhibition | Aeromonas jandaei | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.45 | - |
L-allo-threonine | pH 7.4, temperature not specified in the publication | Aeromonas jandaei | |
| 6.77 | - |
DL-threo-3,4-Dihydroxyphenylserine | pH 7.4, temperature not specified in the publication | Aeromonas jandaei | |
| 19.6 | - |
DL-threo-beta-phenylserine | pH 7.4, temperature not specified in the publication | Aeromonas jandaei | |
| 27.8 | - |
DL-beta-hydroxynorvaline | pH 7.4, temperature not specified in the publication | Aeromonas jandaei | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 38000 | - |
4 * 38000, SDS-PAGE | Aeromonas jandaei |
| 160000 | - |
gel filtration | Aeromonas jandaei |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-allo-threonine | Aeromonas jandaei | - |
glycine + acetaldehyde | - |
? | |
| L-allo-threonine | Aeromonas jandaei DK-39 | - |
glycine + acetaldehyde | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aeromonas jandaei | O07051 | - |
- |
| Aeromonas jandaei DK-39 | O07051 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Aeromonas jandaei |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 37.1 | - |
DL-beta-hydroxynorvaline, pH 7.4, temperature not specified in the publication | Aeromonas jandaei |
| 45.2 | - |
L-allo-threonine, pH 7.4, temperature not specified in the publication | Aeromonas jandaei |
| 208 | - |
DL-threo-beta-phenylserine, pH 7.4, temperature not specified in the publication | Aeromonas jandaei |
| 217 | - |
DL-threo-3,4-dihydroxyphenylserine, pH 7.4, temperature not specified in the publication | Aeromonas jandaei |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DL-beta-hydroxynorvaline + H2O | Vmax/KM is 4% compared to DL-threo-3,4-dihydroxyphenylserine | Aeromonas jandaei | glycine + propionaldehyde | - |
? | |
| DL-beta-hydroxynorvaline + H2O | Vmax/KM is 4% compared to DL-threo-3,4-dihydroxyphenylserine | Aeromonas jandaei DK-39 | glycine + propionaldehyde | - |
? | |
| DL-threo-3,4-dihydroxyphenylserine + H2O | - |
Aeromonas jandaei | glycine + 3,4-dihydroxybenzaldehyde | - |
? | |
| DL-threo-3,4-dihydroxyphenylserine + H2O | - |
Aeromonas jandaei DK-39 | glycine + 3,4-dihydroxybenzaldehyde | - |
? | |
| DL-threo-beta-phenylserine + H2O | Vmax/KM is 33% compared to DL-threo-3,4-dihydroxyphenylserine | Aeromonas jandaei | glycine + benzaldehyde | - |
? | |
| L-allo-threonine | - |
Aeromonas jandaei | glycine + acetaldehyde | - |
? | |
| L-allo-threonine | Vmax/KM is 97% compared to DL-threo-3,4-dihydroxyphenylserine | Aeromonas jandaei | glycine + acetaldehyde | - |
? | |
| L-allo-threonine | - |
Aeromonas jandaei DK-39 | glycine + acetaldehyde | - |
? | |
| L-allo-threonine | Vmax/KM is 97% compared to DL-threo-3,4-dihydroxyphenylserine | Aeromonas jandaei DK-39 | glycine + acetaldehyde | - |
? | |
| additional information | no activity with L-threonine or L-serine | Aeromonas jandaei | ? | - |
? | |
| additional information | no activity with L-threonine or L-serine | Aeromonas jandaei DK-39 | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 38000, SDS-PAGE | Aeromonas jandaei |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| L-allo-threonine acetaldehyde-lyase | - |
Aeromonas jandaei |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Aeromonas jandaei |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | required | Aeromonas jandaei | |
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