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Literature summary for 4.1.2.47 extracted from

  • Von Langermann, J.; Wapenhensch, S.
    Hydroxynitrile lyase-catalyzed synthesis of enantiopure cyanohydrins in Biocatalytic Active Static Emulsions (BASE) with suppression of the non-enzymatic side reaction (2014), Adv. Synth. Catal., 356, 2989-2997 .
No PubMed abstract available
Search for more literature for 4.1.2.47

Application

Application Comment Organism
synthesis use of biocatalytic active static emulsions (BASE) for the hydroxynitrile lyase-catalyzed synthesis of enantiopure cyanohydrins. With this technique a full suppression of the undesired racemic non-enzymatic side reaction is facilitated, even at unusually high pH within the aqueous phase. BASE is an inclusion immobilization. It consists of a hydrophobic matrix, typically polydimethylsiloxane (PDMS), with dispersed domains of an aqueous phase Manihot esculenta

Organism

Organism UniProt Comment Textmining
Manihot esculenta P52705
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyanide + 2-bromobenzaldehyde the (S)-cyanohydrin is formed with more than 99.5% enantiomeric excess Manihot esculenta (S)-2-bromomandelonitrile
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 r
cyanide + 2-chlorobenzaldehyde the (S)-cyanohydrin is formed with more than 99.5% enantiomeric excess Manihot esculenta (S)-2-chloromandelonitrile
-
 r
cyanide + 2-flourobenzaldehyde the (S)-cyanohydrin is formed with more than 99.5% enantiomeric excess Manihot esculenta (S)-2-fluoromandelonitrile
-
 r
cyanide + 3-bromobenzaldehyde the (S)-cyanohydrin is formed with more than 96% enantiomeric excess Manihot esculenta (S)-3-bromomandelonitrile
-
 r
cyanide + 3-chlorobenzaldehyde the (S)-cyanohydrin is formed with more than 96% enantiomeric excess Manihot esculenta (S)-3-chloromandelonitrile
-
 r
cyanide + 3-flourobenzaldehyde the (S)-cyanohydrin is formed with more than 99% enantiomeric excess Manihot esculenta (S)-3-fluoromandelonitrile
-
 r
cyanide + 4-bromobenzaldehyde the (S)-cyanohydrin is formed with more than 99.5% enantiomeric excess Manihot esculenta (S)-4-bromomandelonitrile
-
 r
cyanide + 4-chlorobenzaldehyde the (S)-cyanohydrin is formed with 93% enantiomeric excess Manihot esculenta (S)-4-chloromandelonitrile
-
 r
cyanide + 4-fluorobenzaldehyde the (S)-cyanohydrin is formed with more than 99.5% enantiomeric excess Manihot esculenta (S)-4-fluoromandelonitrile
-
 r
cyanide + benzaldehyde the (S)-cyanohydrin is formed with more than 99.5% enantiomeric excess Manihot esculenta (S)-mandelonitrile
-
 r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
60
-
-
 Manihot esculenta