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Literature summary for 4.1.2.27 extracted from

  • Saba, J.D.
    Fifty years of lyase and a moment of truth sphingosine phosphate lyase from discovery to disease (2019), J. Lipid Res., 60, 456-463.
    View publication on PubMed
Search for more literature for 4.1.2.27

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphinganine 1-phosphate Homo sapiens
-
 phosphoethanolamine + palmitaldehyde
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens O95470
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphinganine 1-phosphate
-
 Homo sapiens phosphoethanolamine + palmitaldehyde
-
 ir

Synonyms

Synonyms Comment Organism
sphingosine phosphate lyase
-
 Homo sapiens
SPL
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate a pyridoxal-phosphate protein Homo sapiens

General Information

General Information Comment Organism
malfunction inactivation causes product depletion and accumulation of upstream sphingolipid intermediates Homo sapiens
malfunction recessive mutations in the human sphingosine phosphate lyase gene SGPL1 are identified as the cause of a novel inborn error of metabolism associated with nephrosis, endocrine defects, immunodeficiency, acanthosis, and neurological problems Homo sapiens
metabolism final enzyme in the sphingolipid degradative pathway. The enzyme guards the sole exit point of sphingolipid metabolism Homo sapiens
physiological function the main substrate of the reaction, sphingosine-1-phosphate, is a bioactive lipid that controls immune-cell trafficking, angiogenesis, cell transformation, and other fundamental processes. The products of the sphingosine phosphate lyase reaction contribute to phospholipid biosynthesis and programmed cell-death activation Homo sapiens