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Literature summary for 4.1.2.27 extracted from

  • Tang, Y.; Ploetz, T.; Graeler, M.H.; Gurgul-Convey, E.
    Sphingosine-1 phosphate lyase regulates sensitivity of pancreatic beta-cells to lipotoxicity (2021), Int. J. Mol. Sci., 22, 10893.
    View publication on PubMed
Search for more literature for 4.1.2.27

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of human enzyme in rat insulin-secreting INS1E cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphinganine 1-phosphate Homo sapiens
-
 phosphoethanolamine + palmitaldehyde
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens O95470
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphinganine 1-phosphate
-
 Homo sapiens phosphoethanolamine + palmitaldehyde
-
 ir

Synonyms

Synonyms Comment Organism
sphingosine-1 phosphate lyase
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism key enzyme of the sphingolipid pathway. The enzyme regulates sensitivity of pancreatic beta-cells to lipotoxicity. Overexpression of sphingosine-1 phosphate lyase in INS1E cells (INS1E-SPL), which are characterized by a moderate basal expression level of sphingosine-1 phosphate lyase, results in an acceleration of palmitate-mediated cell viability loss, proliferation inhibition and induction of oxidative stress. Sphingosine-1 phosphate lyase overexpression affects the mRNA expression of ER stress markers and mitochondrial chaperones Homo sapiens