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Literature summary for 4.1.2.27 extracted from

  • Uranbileg, B.; Kurano, M.; Kano, K.; Sakai, E.; Arita, J.; Hasegawa, K.; Nishikawa, T.; Ishihara, S.; Yamashita, H.; Seto, Y.; Ikeda, H.; Aoki, J.; Yatomi, Y.
    Sphingosine 1-phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids (2022), Clin. Transl. Med., 12, e1056.
    View publication on PubMed
Search for more literature for 4.1.2.27

Organism

Organism UniProt Comment Textmining
Homo sapiens O95470
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Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
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 Homo sapiens
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esophageal cancer cell
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 Homo sapiens
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hepatoma cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
sphingosine 1-phosphate lyase
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 Homo sapiens

General Information

General Information Comment Organism
drug target pharmacological inhibition of sphingosine 1-phosphate lyase prevents the progression of cancer Homo sapiens
metabolism sphingosine 1-phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids. Overexpression of sphingosine 1-phosphate lyase in Colon 26 cells results in elevated levels of lysophosphatidylinositol and lysophosphatidylglycerol, which are agonists of GPR55. Sphingosine 1-phosphate lyase overexpression-enhanced cell proliferation is inhibited by GPR55 silencing. Contribution of sphingosine 1-phosphate lyase and glycerolyssphingosine 1-phosphate lyase to tumour progression depending on levels of sphingosine 1-phosphate lyase and GPR55. The underlying mechanisms for the SPL-mediated cancer progression are the activation of p38 and mitochondrial function through the lysophosphatidylinositol, lysophosphatidylglycerol-GPR55 axis and the suppression of autophagy in a GPR55-independent manner Homo sapiens