Literature summary for 4.1.2.27 extracted from

Schuemann, J.; Grevot, A.; Ledieu, D.; Wolf, A.; Schubart, A.; Piaia, A.; Sutter, E.; Cote, S.; Beerli, C.; Pognan, F.; Billich, A.; Moulin, P.; Walker, U.J.
Reduced activity of sphingosine-1-phosphate lyase induces podocyte-related glomerular proteinuria, skin irritation, and platelet activation (2015), Toxicol. Pathol., 43, 694-703 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
[(4-benzyl-phthalazin-1-yl)-2-methylpiperazin-1-yl]-nicotinonitrile	-	Mus musculus
[(4-benzyl-phthalazin-1-yl)-2-methylpiperazin-1-yl]-nicotinonitrile	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
sphinganine 1-phosphate	Mus musculus	-	phosphoethanolamine + palmitaldehyde	-	?
sphinganine 1-phosphate	Rattus norvegicus	-	phosphoethanolamine + palmitaldehyde	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
sphinganine 1-phosphate	-	Mus musculus	phosphoethanolamine + palmitaldehyde	-	?
sphinganine 1-phosphate	-	Rattus norvegicus	phosphoethanolamine + palmitaldehyde	-	?

Synonyms

Synonyms	Comment	Organism
S1P lyase	-	Mus musculus
S1P lyase	-	Rattus norvegicus
sphingosine-1-phosphate lyase	-	Mus musculus
sphingosine-1-phosphate lyase	-	Rattus norvegicus

General Information

General Information	Comment	Organism
malfunction	enzyme inhibition causes protein-losing glomerulopathy due to podocyte dysfunction, skin irritation, and platelet activation and may also be associated with pathological alterations in other tissues such as lung, liver, thymus, and the red blood cell system	Mus musculus
malfunction	enzyme inhibition causes protein-losing glomerulopathy due to podocyte dysfunction, skin irritation, and platelet activation and may also be associated with pathological alterations in other tissues such as lung, liver, thymus, and the red blood cell system	Rattus norvegicus

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Release 2023.1 (January 2023)