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Literature summary for 4.1.2.27 extracted from

  • Custodio, R.; McLean, C.J.; Scott, A.E.; Lowther, J.; Kennedy, A.; Clarke, D.J.; Campopiano, D.J.; Sarkar-Tyson, M.; Brown, A.R.
    Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei (2016), Mol. Microbiol., 102, 1004-1019 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by D-erythro-sphingosine Burkholderia pseudomallei
additional information not inhibited by D-erythro-sphingosine Burkholderia thailandensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphinganine 1-phosphate Burkholderia pseudomallei
-
phosphoethanolamine + palmitaldehyde
-
ir
sphinganine 1-phosphate Burkholderia thailandensis
-
phosphoethanolamine + palmitaldehyde
-
ir
sphinganine 1-phosphate Burkholderia pseudomallei K96243
-
phosphoethanolamine + palmitaldehyde
-
ir

Organism

Organism UniProt Comment Textmining
Burkholderia pseudomallei
-
-
-
Burkholderia pseudomallei K96243
-
-
-
Burkholderia thailandensis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphinganine 1-phosphate
-
Burkholderia pseudomallei phosphoethanolamine + palmitaldehyde
-
ir
sphinganine 1-phosphate
-
Burkholderia thailandensis phosphoethanolamine + palmitaldehyde
-
ir
sphinganine 1-phosphate
-
Burkholderia pseudomallei K96243 phosphoethanolamine + palmitaldehyde
-
ir

Subunits

Subunits Comment Organism
? x * 60000, FLAG-tagged enzyme, SDS-PAGE Burkholderia pseudomallei
? x * 60000, FLAG-tagged enzyme, SDS-PAGE Burkholderia thailandensis

Synonyms

Synonyms Comment Organism
S1P lyase
-
Burkholderia pseudomallei
S1P lyase
-
Burkholderia thailandensis
S1PL
-
Burkholderia pseudomallei
S1PL
-
Burkholderia thailandensis
sphingosine-1-phosphate lyase
-
Burkholderia pseudomallei
sphingosine-1-phosphate lyase
-
Burkholderia thailandensis

General Information

General Information Comment Organism
malfunction enzyme-deficient mutants display impaired intracellular replication in murine macrophages (associated with an inability to evade the maturing phagosome) Burkholderia pseudomallei
malfunction enzyme-deficient mutants display impaired intracellular replication in murine macrophages (associated with an inability to evade the maturing phagosome) Burkholderia thailandensis
physiological function the enzyme plays a critical role in virulence and is required for intracellular survival Burkholderia pseudomallei
physiological function the enzyme plays a critical role in virulence and is required for intracellular survival Burkholderia thailandensis