Literature summary for 4.1.2.27 extracted from

Sanllehi, P.; Abad, J.L.; Bujons, J.; Casas, J.; Delgado, A.
Studies on the inhibition of sphingosine-1-phosphate lyase by stabilized reaction intermediates and stereodefined azido phosphates (2016), Eur. J. Med. Chem., 123, 905-915 .

Inhibitors

Inhibitors	Comment	Organism
(2R,3R)-2-azido-3-hydroxyoctadecyl phosphate	-	Homo sapiens
(2R,3R)-2-azido-3-hydroxyoctadecyl phosphate	-	Symbiobacterium thermophilum
(2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate	-	Homo sapiens
(2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate	-	Symbiobacterium thermophilum
(2R,3S)-2-azido-3-hydroxyoctadecyl phosphate	-	Homo sapiens
(2R,3S)-2-azido-3-hydroxyoctadecyl phosphate	-	Symbiobacterium thermophilum
(2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate	-	Homo sapiens
(2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate	-	Symbiobacterium thermophilum
(2S,3R)-2-azido-3-hydroxyoctadecyl phosphate	-	Homo sapiens
(2S,3R)-2-azido-3-hydroxyoctadecyl phosphate	-	Symbiobacterium thermophilum
(2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate	-	Homo sapiens
(2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate	-	Symbiobacterium thermophilum
(2S,3S)-2-azido-3-hydroxyoctadecyl phosphate	-	Homo sapiens
(2S,3S)-2-azido-3-hydroxyoctadecyl phosphate	-	Symbiobacterium thermophilum
(2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate	-	Homo sapiens
(2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate	-	Symbiobacterium thermophilum
1-deoxysphinganine 1-phosphonate	-	Homo sapiens
1-deoxysphinganine 1-phosphonate	-	Symbiobacterium thermophilum
2-vinyldihydrosphingosine 1-phosphate	-	Homo sapiens
2-vinyldihydrosphingosine 1-phosphate	-	Symbiobacterium thermophilum
4-deoxypyridoxine	-	Homo sapiens
4-deoxypyridoxine	-	Symbiobacterium thermophilum
FTY720	-	Homo sapiens
FTY720	-	Symbiobacterium thermophilum
phosphopyridoxyl sphinganine 1-phosphate	-	Homo sapiens
phosphopyridoxyl sphinganine 1-phosphate	-	Symbiobacterium thermophilum
phosphopyridoxyl sphingosine 1-phosphate	-	Homo sapiens
phosphopyridoxyl sphingosine 1-phosphate	-	Symbiobacterium thermophilum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Homo sapiens	5783	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
sphinganine 1-phosphate	Homo sapiens	-	phosphoethanolamine + palmitaldehyde	-	ir
sphinganine 1-phosphate	Symbiobacterium thermophilum	-	phosphoethanolamine + palmitaldehyde	-	ir

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Symbiobacterium thermophilum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
RBM13	-	Homo sapiens	?	-	?
RBM13	-	Symbiobacterium thermophilum	?	-	?
sphinganine 1-phosphate	-	Homo sapiens	phosphoethanolamine + palmitaldehyde	-	ir
sphinganine 1-phosphate	-	Symbiobacterium thermophilum	phosphoethanolamine + palmitaldehyde	-	ir

Synonyms

Synonyms	Comment	Organism
S1PL	-	Homo sapiens
S1PL	-	Symbiobacterium thermophilum
sphingosine-1-phosphate lyase	-	Homo sapiens
sphingosine-1-phosphate lyase	-	Symbiobacterium thermophilum

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Homo sapiens
pyridoxal 5'-phosphate	-	Symbiobacterium thermophilum

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism
0.005	-	1-deoxysphinganine 1-phosphonate	at pH 10.6 and 37°C	Homo sapiens
0.005	-	1-deoxysphinganine 1-phosphonate	at pH 10.6 and 37°C	Symbiobacterium thermophilum
0.0056	-	(2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate	at pH 10.6 and 37°C	Homo sapiens
0.0063	-	(2R,3S)-2-azido-3-hydroxyoctadecyl phosphate	at pH 10.6 and 37°C	Homo sapiens
0.0091	-	(2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate	at pH 10.6 and 37°C	Homo sapiens
0.0164	-	(2S,3S)-2-azido-3-hydroxyoctadecyl phosphate	at pH 10.6 and 37°C	Homo sapiens
0.0175	-	(2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate	at pH 10.6 and 37°C	Homo sapiens
0.019	-	(2S,3R)-2-azido-3-hydroxyoctadecyl phosphate	at pH 10.6 and 37°C	Homo sapiens
0.0204	-	(2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate	at pH 10.6 and 37°C	Homo sapiens
0.0367	-	(2R,3R)-2-azido-3-hydroxyoctadecyl phosphate	at pH 10.6 and 37°C	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.0024	-	at pH 10.6 and 37°C	Homo sapiens	2-vinyldihydrosphingosine 1-phosphate
0.0024	-	at pH 10.6 and 37°C	Symbiobacterium thermophilum	2-vinyldihydrosphingosine 1-phosphate
0.0052	-	at pH 10.6 and 37°C	Homo sapiens	(2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0101	-	at pH 10.6 and 37°C	Homo sapiens	(2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0108	-	at pH 10.6 and 37°C	Homo sapiens	(2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
0.0117	-	at pH 10.6 and 37°C	Symbiobacterium thermophilum	(2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0129	-	at pH 10.6 and 37°C	Symbiobacterium thermophilum	(2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0138	-	at pH 10.6 and 37°C	Symbiobacterium thermophilum	(2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.016	-	at pH 10.6 and 37°C	Symbiobacterium thermophilum	(2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0218	-	at pH 10.6 and 37°C	Homo sapiens	(2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
0.0229	-	at pH 10.6 and 37°C	Homo sapiens	(2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.0243	-	at pH 10.6 and 37°C	Symbiobacterium thermophilum	(2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
0.025	-	at pH 10.6 and 37°C	Symbiobacterium thermophilum	(2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
0.0257	-	at pH 10.6 and 37°C	Homo sapiens	(2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
0.0257	-	at pH 10.6 and 37°C	Symbiobacterium thermophilum	(2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
0.0272	-	at pH 10.6 and 37°C	Symbiobacterium thermophilum	(2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
0.0283	-	at pH 10.6 and 37°C	Homo sapiens	(2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
0.0288	-	at pH 10.6 and 37°C	Homo sapiens	(2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
0.047	-	at pH 10.6 and 37°C	Symbiobacterium thermophilum	phosphopyridoxyl sphinganine 1-phosphate
0.0524	-	at pH 10.6 and 37°C	Homo sapiens	FTY720
0.0524	-	at pH 10.6 and 37°C	Symbiobacterium thermophilum	FTY720
0.0534	-	at pH 10.6 and 37°C	Symbiobacterium thermophilum	phosphopyridoxyl sphingosine 1-phosphate
0.0811	-	at pH 10.6 and 37°C	Homo sapiens	phosphopyridoxyl sphinganine 1-phosphate
0.089	-	at pH 10.6 and 37°C	Homo sapiens	phosphopyridoxyl sphingosine 1-phosphate