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Literature summary for 4.1.2.27 extracted from

  • Huwiler, A.; Bourquin, F.; Kotelevets, N.; Pastukhov, O.; Capitani, G.; Gruetter, M.G.; Zangemeister-Wittke, U.
    A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders (2011), PLoS ONE, 6, e22436.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.2.27

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Symbiobacterium thermophilum

Protein Variants

Protein Variants Comment Organism
K311A inactive Symbiobacterium thermophilum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 x * 55000, SDS-PAGE Symbiobacterium thermophilum

Organism

Organism UniProt Comment Textmining
Symbiobacterium thermophilum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Symbiobacterium thermophilum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingosine 1-phosphate SPL from Symbiobacterium thermophilum degrades extracellular sphingosine 1-phosphate in vitro and in blood Symbiobacterium thermophilum phosphoethanolamine + (2E)-hexadecenal
-
 ?

Subunits

Subunits Comment Organism
? x * 55000, SDS-PAGE Symbiobacterium thermophilum

Synonyms

Synonyms Comment Organism
S1P lyase
-
 Symbiobacterium thermophilum
SPL
-
 Symbiobacterium thermophilum

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Symbiobacterium thermophilum

General Information

General Information Comment Organism
physiological function in renal mesangial cells, endothelial cells, breast (MCF-7) and colon (HCT 116) carcinoma cells, wild type SPL from Symbiobacterium thermophilum disrupts MAPK phosphorylation stimulated by exogenous sphingosine 1-phosphate. Under in vivo conditions SPL from Symbiobacterium thermophilum inhibits tumor cell-induced angiogenesis as an sphingosine 1-phosphate-dependent process Symbiobacterium thermophilum