Literature summary for 4.1.2.27 extracted from

Min, J.; Van Veldhoven, P.P.; Zhang, L.; Hanigan, M.H.; Alexander, H.; Alexander, S.
Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner (2005), Mol. Cancer Res., 3, 287-296.

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Inhibitors

Inhibitors	Comment	Organism	Structure
carboplatin	cells overexpressing enzyme show increased sensitivity	Homo sapiens
cisplatin	cells overexpressing enzyme show increased sensitivity, mediated by death kinase p38	Homo sapiens
doxorubicin	cells overexpressing enzyme show increased sensitivity	Homo sapiens
additional information	overexpression of enzyme, no change in sensitivity to vincristine, chlorambucil	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	expression in HEK293 or A459 cells	-

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Release 2026.1 (March 2026)