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Literature summary for 4.1.2.27 extracted from
- The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity (2005), J. Biol. Chem., 280, 33697-33700.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | some effects of immune modulator FTY720 are due to disruption of sphingosine-1-phosphate metabolism | Homo sapiens |
| medicine | some effects of immune modulator FTY720 are due to disruption of sphingosine-1-phosphate metabolism | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| FTY720 | in vitro inhibition of enzyme, effects occurring from 300 nM concentrations on, maximal effects at 0.03 mM | Homo sapiens |  |
| FTY720 | in vivo enzyme inhibition concommitantly with lymphopenia, neither enzyme gene expression nor tissue enzyme protein expression is affected by inhibior | Mus musculus | |
| FTY720 phosphate | less potent inhibitor than FTY720, effects only at 0.03 mM | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
expression in HEK293 cell | - |
| Mus musculus | - |
female, 4 weeks old | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| thymus | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SPL | - |
Homo sapiens |
| SPL | - |
Mus musculus |
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