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Literature summary for 4.1.2.27 extracted from
- Sphingosine-phosphate lyase (1993), Adv. Lipid Res., 26, 69-98.
General Stability
| General Stability | Organism |
|---|---|
| embedded in its lipid environment liver enzyme is quite stable | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2D,3L-sphinganine-phosphate | competitive | Tetrahymena pyriformis |  |
| additional information | enzyme is sensitive toward neutral detergents | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.11 | - |
sphinganine-phosphate | - |
Tetrahymena pyriformis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Sus scrofa | - |
- |
| microsome | highest enzyme activity | Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Cavia porcellus | metabolic pathways of the enzyme substrates | ? | - |
? | |
| additional information | Mus musculus | metabolic pathways of the enzyme substrates | ? | - |
? | |
| additional information | Homo sapiens | metabolic pathways of the enzyme substrates | ? | - |
? | |
| additional information | Rattus norvegicus | metabolic pathways of the enzyme substrates | ? | - |
? | |
| additional information | Sus scrofa | metabolic pathways of the enzyme substrates | ? | - |
? | |
| additional information | Tetrahymena pyriformis | metabolic pathways of the enzyme substrates | ? | - |
? | |
| additional information | Canis lupus familiaris | metabolic pathways of the enzyme substrates | ? | - |
? | |
| additional information | Platyrrhini | metabolic pathways of the enzyme substrates | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
- |
- |
| Cavia porcellus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
Swiss mouse | - |
| Platyrrhini | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
| Tetrahymena pyriformis | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde | enzyme has been classified within the group of carbon-carbon lyases a subclass of aldehyde-lyases (Enzyme Nomenclature 1984) | Rattus norvegicus | |
| Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde | enzyme has been classified within the group of carbon-carbon lyases a subclass of aldehyde-lyases (Enzyme Nomenclature 1984) | Sus scrofa | |
| Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde | enzyme has been classified within the group of carbon-carbon lyases a subclass of aldehyde-lyases (Enzyme Nomenclature 1984) | Tetrahymena pyriformis | |
| Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde | enzyme has been classified within the group of carbon-carbon lyases a subclass of aldehyde-lyases (Enzyme Nomenclature 1984) | Cavia porcellus | |
| Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde | enzyme has been classified within the group of carbon-carbon lyases a subclass of aldehyde-lyases (Enzyme Nomenclature 1984) | Homo sapiens | |
| Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde | enzyme has been classified within the group of carbon-carbon lyases a subclass of aldehyde-lyases (Enzyme Nomenclature 1984) | Mus musculus | |
| Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde | enzyme has been classified within the group of carbon-carbon lyases a subclass of aldehyde-lyases (Enzyme Nomenclature 1984) | Canis lupus familiaris | |
| Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde | enzyme has been classified within the group of carbon-carbon lyases a subclass of aldehyde-lyases (Enzyme Nomenclature 1984) | Platyrrhini |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| 3T3-L1 cell | CL 173 (ATCC) | Mus musculus | - |
| A7r5 cell | CRL 1444 (ATCC) | Rattus norvegicus | - |
| BC3H1 cell | CRL 1443 (ATCC) | Mus musculus | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Mus musculus | - |
| C2C12 cell | CRL 1772 (ATCC) | Mus musculus | - |
| cerebellum | - |
Rattus norvegicus | - |
| embryonic fibroblast cell line | CCL92 (ATCC) | Mus musculus | - |
| fibroblast | - |
Homo sapiens | - |
| harderian gland | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| heart | - |
Mus musculus | - |
| HeLa cell | CCL2 (ATCC) | Homo sapiens | - |
| Hep-G2 cell | HB 8065 (ATTC) | Homo sapiens | - |
| intestinal mucosa | - |
Cavia porcellus | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Sus scrofa | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Canis lupus familiaris | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Sus scrofa | - |
| liver | - |
Mus musculus | - |
| LLC-PK1 cell | CRL 1392 (ATCC) | Sus scrofa | - |
| lung | - |
Rattus norvegicus | - |
| lung | - |
Mus musculus | - |
| MDCK cell | CCL 34 (ATCC) | Canis lupus familiaris | - |
| muscle | skeletal muscle | Rattus norvegicus | - |
| pancreas | - |
Rattus norvegicus | - |
| skeletal muscle | - |
Rattus norvegicus | - |
| spinal cord | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
| telencephalon | - |
Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
overview | Rattus norvegicus |
| additional information | - |
overview | Sus scrofa |
| additional information | - |
overview | Tetrahymena pyriformis |
| additional information | - |
overview | Cavia porcellus |
| additional information | - |
overview | Homo sapiens |
| additional information | - |
overview | Mus musculus |
| additional information | - |
overview | Canis lupus familiaris |
| additional information | - |
overview | Platyrrhini |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, liver enzyme loses 25% of activity for up to 2 month | Rattus norvegicus |
| -20°C, lyophilized microsomal preparations retain their full activity | Rattus norvegicus |
| -80°C, liver enzyme loses 10-15% of activity for up to 2 months | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | metabolic pathways of the enzyme substrates | Cavia porcellus | ? | - |
? | |
| additional information | metabolic pathways of the enzyme substrates | Mus musculus | ? | - |
? | |
| additional information | metabolic pathways of the enzyme substrates | Homo sapiens | ? | - |
? | |
| additional information | metabolic pathways of the enzyme substrates | Rattus norvegicus | ? | - |
? | |
| additional information | metabolic pathways of the enzyme substrates | Sus scrofa | ? | - |
? | |
| additional information | metabolic pathways of the enzyme substrates | Tetrahymena pyriformis | ? | - |
? | |
| additional information | metabolic pathways of the enzyme substrates | Canis lupus familiaris | ? | - |
? | |
| additional information | metabolic pathways of the enzyme substrates | Platyrrhini | ? | - |
? | |
| sphingosine 1-phosphate | sphingenine-phosphate | Cavia porcellus | phosphoethanolamine + palmitaldehyde | - |
? | |
| sphingosine 1-phosphate | sphingenine-phosphate | Mus musculus | phosphoethanolamine + palmitaldehyde | - |
? | |
| sphingosine 1-phosphate | sphingenine-phosphate | Homo sapiens | phosphoethanolamine + palmitaldehyde | - |
? | |
| sphingosine 1-phosphate | sphingenine-phosphate | Rattus norvegicus | phosphoethanolamine + palmitaldehyde | - |
? | |
| sphingosine 1-phosphate | sphingenine-phosphate | Sus scrofa | phosphoethanolamine + palmitaldehyde | - |
? | |
| sphingosine 1-phosphate | sphingenine-phosphate | Tetrahymena pyriformis | phosphoethanolamine + palmitaldehyde | - |
? | |
| sphingosine 1-phosphate | sphingenine-phosphate | Canis lupus familiaris | phosphoethanolamine + palmitaldehyde | - |
? | |
| sphingosine 1-phosphate | sphingenine-phosphate | Platyrrhini | phosphoethanolamine + palmitaldehyde | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
| pyridoxal 5'-phosphate | - |
Tetrahymena pyriformis | |
| pyridoxal 5'-phosphate | - |
Mus musculus | |
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