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Literature summary for 4.1.2.25 extracted from

  • Mathis, J.B.; Brown, G.M.
    The biosynthesis of folic acid. XI. Purification and properties of dihydroneopterin aldolase (1970), J. Biol. Chem., 245, 3015-3025.
    View publication on PubMed
Search for more literature for 4.1.2.25

Activating Compound

Activating Compound Comment Organism Structure
EDTA increases activity Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine competitive Escherichia coli
dihydrofolic acid
-
 Escherichia coli
Dihydropteroic acid slight Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.009
-
 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli B / ATCC 11303
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0039
-
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
-
 Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde
-
 ?
2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
-
 Escherichia coli B / ATCC 11303 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde
-
 ?
2-amino-4-hydroxy-6-(L-threo-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
-
 Escherichia coli ?
-
 ?
2-amino-4-hydroxy-6-(L-threo-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
-
 Escherichia coli B / ATCC 11303 ?
-
 ?
additional information no activity with: 2-amino-4-hydroxy-6-(D-threo-1,2,3-trihydroxypropyl)-7,8-dihydropteridine and 2-amino-4-hydroxy-6-(L-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine Escherichia coli ?
-
 ?
additional information no activity with: 2-amino-4-hydroxy-6-(D-threo-1,2,3-trihydroxypropyl)-7,8-dihydropteridine and 2-amino-4-hydroxy-6-(L-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine Escherichia coli B / ATCC 11303 ?
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
100
-
 5 min, stable Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.6
-
-
 Escherichia coli