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Literature summary for 4.1.2.13 extracted from

  • Ciesla, M.; Mierzejewska, J.; Adamczyk, M.; Farrants, A.K.; Boguta, M.
    Fructose bisphosphate aldolase is involved in the control of RNA polymerase III-directed transcription (2014), Biochim. Biophys. Acta, 1843, 1103-1110.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Synonyms

Synonyms Comment Organism
Fba1
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Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function the overproduction of fructose bisphosphate aldolase Fba1 enables overcoming of a severe growth defect caused by a missense mutation rpc128-1007 in a gene encoding the C128 protein, the second largest subunit of the RNA polymerase III complex. The suppression of the growth phenotype by Fba1 is accompanied by enhanced de novo tRNA transcription in rpc128-1007 cells. Overproduction of an inactive aldolase mutant still suppresses the rpc128-1007 phenotype, and Fba1 interacts with the RNA polymerase III complex and plays a role in control of tRNA transcription Saccharomyces cerevisiae