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Literature summary for 4.1.1.B12 extracted from

  • Yamaguchi, Y.; Takatsuka, Y.; Kamio, Y.
    Two segments in bacterial Antizyme P22 are essential for binding and enhance degradation of lysine/pornithine decarboxylase in Selenomonas ruminantium (2008), J. Bacteriol., 190, 442-446 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.B12

Cloned(Commentary)

Cloned (Comment) Organism
gene ldc, DNA and amino acid sequence determination and analysis, recombinant expression of His-tagged LDC/ODC in Escherichia coli Selenomonas ruminantium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine Selenomonas ruminantium
-
 cadaverine + CO2
-
 ?
L-ornithine Selenomonas ruminantium
-
 putrescine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Selenomonas ruminantium O50657
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information the degradation of lysine/ornithine decarboxylase (LDC/ODC) by ATP-requiring protease(s) is accelerated by the binding of Antizyme P22, which is a ribosomal protein of this strain. Antizyme P22 has a unique 5-residue K101NKLD105 segment and an 11-residue G160VIRNAVYVLD170 segment. The two segments of P22 are crucial for P22 binding to the enzyme and also accelerate degradation of the decarboxylase, mutational analysis, overview Selenomonas ruminantium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine
-
 Selenomonas ruminantium cadaverine + CO2
-
 ?
L-ornithine
-
 Selenomonas ruminantium putrescine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
LDC
-
 Selenomonas ruminantium
LDC/ODC
-
 Selenomonas ruminantium
lysine/ornithine decarboxylase
-
 Selenomonas ruminantium
More cf. EC 4.1.1.17 Selenomonas ruminantium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Selenomonas ruminantium

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Selenomonas ruminantium

General Information

General Information Comment Organism
metabolism the degradation of lysine/ornithine decarboxylase (LDC/ODC) by ATP-requiring protease(s) is accelerated by the binding of Antizyme P22, which is a ribosomal protein of the strain Selenomonas ruminantium