Activating Compound | Comment | Organism | Structure |
---|---|---|---|
N-ethyl-2-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)hexadecylamide | 2fold higher carboxylated osteocalcin synthesis in MG-63 cells in presence of the compound than with menaquinone-4. No cytotoxicity observed with concentrations up to 500 nM | Homo sapiens | |
N-ethyl-2-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)tetradecylamide | - |
Rattus norvegicus | |
N-ethyl-2-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)tetradecylamide | 2.5fold higher carboxylated osteocalcin synthesis in MG-63 cells in presence of the compound than with menaquinone-4, No cytotoxicity observed with concentrations up to 500 nM | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | in WKY rats receiving a vitamin K-deficient diet that results in a 40% decrease of prothrombin activity, compound N-ethyl-2-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)tetradecylamide is able to counteract the effects on vitamin K deficiency and results in the complete restoration of prothrombin activity | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MG-63 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
osteocalcin + reduced vitamin K + CO2 + O2 | - |
Homo sapiens | carboxylated osteocalcin + vitamin K epoxide + H2O | - |
? |