Literature summary for 4.1.1.90 extracted from

Vermeer, C.; van t Hoofd, C.; Knapen, M.H.J.; Xanthoulea, S.
Synthesis of 2-methyl-1,4-naphthoquinones with higher gamma-glutamyl carboxylase activity than MK-4 both in vitro and in vivo (2017), Bioorg. Med. Chem. Lett., 27, 208-211 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
N-ethyl-2-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)hexadecylamide	2fold higher carboxylated osteocalcin synthesis in MG-63 cells in presence of the compound than with menaquinone-4. No cytotoxicity observed with concentrations up to 500 nM	Homo sapiens
N-ethyl-2-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)tetradecylamide	-	Rattus norvegicus
N-ethyl-2-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)tetradecylamide	2.5fold higher carboxylated osteocalcin synthesis in MG-63 cells in presence of the compound than with menaquinone-4, No cytotoxicity observed with concentrations up to 500 nM	Homo sapiens

Application

Application	Comment	Organism
medicine	in WKY rats receiving a vitamin K-deficient diet that results in a 40% decrease of prothrombin activity, compound N-ethyl-2-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)tetradecylamide is able to counteract the effects on vitamin K deficiency and results in the complete restoration of prothrombin activity	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MG-63 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
osteocalcin + reduced vitamin K + CO2 + O2	-	Homo sapiens	carboxylated osteocalcin + vitamin K epoxide + H2O	-	?

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Release 2023.1 (January 2023)