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Literature summary for 4.1.1.90 extracted from

  • Parker, C.H.; Morgan, C.R.; Rand, K.D.; Engen, J.R.; Jorgenson, J.W.; Stafford, D.W.
    A conformational investigation of propeptide binding to the integral membrane protein gamma-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry (2014), Biochemistry, 53, 1511-1520 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.90

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 cell Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
FLEEL + CO2 + O2 + proFIX 19
-
 Homo sapiens ? + vitamin K epoxide + H2O
-
 ?

General Information

General Information Comment Organism
physiological function characterization of specific domains of GGCX that exhibit structural rearrangements upon binding the high-affinity consensus propeptide pCon (AVFLSREQANQVLQRRRR). pCon binding is specific for monomeric GGCX-nanodiscs and promotes enhanced structural stability to the nanodisc-integrated complex while maintaining catalytic activity in the presence of carboxylation cosubstrates. Modifications in hydrogen exchange of GGCX are prominently observed in GGCX peptides 491-507 and 395-401 upon pCon association, consistent with sites for propeptide and glutamate binding Homo sapiens