Literature summary for 4.1.1.90 extracted from

Morris, D.P.; Soute, B.A.; Vermeer, C.; Stafford, D.W.
Characterization of the purified vitamin K-dependent gamma-glutamyl carboxylase (1993), J. Biol. Chem., 268, 8735-8742.

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General Stability

General Stability	Organism
freeze-thawing, three times, stable	Bos taurus

Inhibitors

Inhibitors	Comment	Organism	Structure
N-ethylmaleimide	-	Bos taurus
warfarin	-	Bos taurus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.3	-	CO2	pH 7.4	Bos taurus
1.6	-	FLEEL	pH 7.4	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Bos taurus	-	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	Q07175	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Bos taurus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Bos taurus	-

Storage Stability

Storage Stability	Organism
-70°C, 6 months, stable	Bos taurus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
FLEEL + CO2 + O2 + phylloquinone	-	Bos taurus	? + 2,3-epoxyphylloquinone + H2O	-	?

Synonyms

Synonyms	Comment	Organism
gamma-glutamyl carboxylase	-	Bos taurus

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
1	-	CO2	pH 7.4	Bos taurus

Cofactor

Cofactor	Comment	Organism	Structure
phylloquinone	-	Bos taurus

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Release 2023.1 (January 2023)