BRENDA - Enzyme Database
show all sequences of 4.1.1.90

Cloning of rat vitamin K-dependent gamma-glutamyl carboxylase and developmentally regulated gene expression in postimplantation embryos

Romero, E.E.; Velazquez-Estades, L.J.; Deo, R.; Schapiro, B.; Roth, D.A.; Exp. Cell Res. 243, 334-346 (1998)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
-
Rattus norvegicus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
85700
-
calculated from sequence
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-glutamate + CO2 + O2 + vitamin K hydroquinone
Rattus norvegicus
-
gamma-carboxy L-glutamate + vitamin K epoxide + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
O88496
Sprague-Dawley rat
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adipose tissue
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
embryo
vitamin K-dependent carboxylase mRNA expression in early rat embryonic development
Rattus norvegicus
-
H4-II-E-C3 cell
rat hepatoma cell line
Rattus norvegicus
-
heart
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
kidney
adult Sprague-Dawley rat
Rattus norvegicus
-
liver
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
lung
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
muscle
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
ovary
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
pancreas
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
spleen
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
stomach
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
testis
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-glutamate + CO2 + O2 + vitamin K hydroquinone
-
697786
Rattus norvegicus
gamma-carboxy L-glutamate + vitamin K epoxide + H2O
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
vitamin K
-
Rattus norvegicus
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
vitamin K
-
Rattus norvegicus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
85700
-
calculated from sequence
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-glutamate + CO2 + O2 + vitamin K hydroquinone
Rattus norvegicus
-
gamma-carboxy L-glutamate + vitamin K epoxide + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adipose tissue
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
embryo
vitamin K-dependent carboxylase mRNA expression in early rat embryonic development
Rattus norvegicus
-
H4-II-E-C3 cell
rat hepatoma cell line
Rattus norvegicus
-
heart
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
kidney
adult Sprague-Dawley rat
Rattus norvegicus
-
liver
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
lung
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
muscle
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
ovary
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
pancreas
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
spleen
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
stomach
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
testis
expression of rat vitamin K-dependent carboxylase in adult and embryonic tissues
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-glutamate + CO2 + O2 + vitamin K hydroquinone
-
697786
Rattus norvegicus
gamma-carboxy L-glutamate + vitamin K epoxide + H2O
-
-
-
?
Other publictions for EC 4.1.1.90
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747280
Vermeer
Synthesis of 2-methyl-1,4-nap ...
Homo sapiens, Rattus norvegicus
Bioorg. Med. Chem. Lett.
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208-211
2017
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747630
Nagahashi
Successful synthesis of activ ...
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Cytotechnology
69
317-327
2017
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1
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746967
Shiba
gamma-Glutamyl carboxylase in ...
Mus musculus
Biochem. Biophys. Res. Commun.
453
350-355
2014
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747068
Parker
A conformational investigatio ...
Homo sapiens
Biochemistry
53
1511-1520
2014
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1
1
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726845
Haraikawa
Effects of gamma-glutamyl carb ...
Homo sapiens
Asia Pac. J. Clin. Nutr.
22
646-654
2013
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726673
Kaesler
A fluorescent method to determ ...
Rattus norvegicus
Anal. Biochem.
421
411-416
2012
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2
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2
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1
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1
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715657
Rishavy
Novel insight into the mechani ...
Homo sapiens
J. Biol. Chem.
286
7267-7278
2011
-
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1
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2
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1
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1
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716060
Wu
A hetero-dimer model for conce ...
Homo sapiens
J. Theor. Biol.
279
143-149
2011
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1
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1
1
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705218
Li
The mineralization phenotype i ...
Mus musculus
J. Mol. Med.
88
173-181
2010
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706879
Wang
Activity and expression of vit ...
Homo sapiens
Urol. Int.
85
94-99
2010
-
-
-
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1
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1
1
1
1
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715064
Krossøy
Vitamin K-dependent gamma-glut ...
Salmo salar
Fish Physiol. Biochem.
36
627-635
2010
1
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1
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1
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3
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6
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1
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2
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1
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2
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6
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1
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716953
King
Gamma-glutamyl carboxylase and ...
Homo sapiens
Thromb. Haemost.
104
750-754
2010
-
1
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1
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1
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1
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2
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699704
Crosier
Association of sequence variat ...
Homo sapiens
J. Nutr. Sci. Vitaminol.
55
112-119
2009
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2
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1
1
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701616
Li
Co-existent pseudoxanthoma ela ...
Homo sapiens
Am. J. Pathol.
174
534-540
2009
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1
1
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703270
Rai
A multiplex assay for detectin ...
Homo sapiens
Clin. Chem.
55
823-826
2009
-
1
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2
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1
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704939
Qiao
Genetic mutation of vitamin K- ...
Homo sapiens
J. Huazhong Univ. Sci. Technol. Med. Sci.
29
604-608
2009
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1
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706075
Titapiwatanakun
Novel splice site mutations in ...
Homo sapiens
Pediatr. Blood Cancer
53
92-95
2009
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1
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696271
Tie
Transmembrane domain interacti ...
Homo sapiens
Biochemistry
47
6301-6310
2008
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1
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9
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2
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1
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2
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1
1
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1
1
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9
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696930
Zhu
Fatal hemorrhage in mice lacki ...
Mus musculus
Blood
109
5270-5275
2007
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1
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4
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699400
Vanakker
Pseudoxanthoma elasticum-like ...
Homo sapiens
J. Invest. Dermatol.
127
581-587
2007
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1
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1
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672089
Rishavy
Bronsted analysis reveals Lys2 ...
Homo sapiens
Biochemistry
45
13239-13248
2006
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1
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4
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1
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1
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3
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1
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1
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1
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4
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3
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1
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2
1
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700930
Kulman
Vitamin K-dependent proteins i ...
Ciona intestinalis
Proc. Natl. Acad. Sci. USA
103
15794-15799
2006
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