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Literature summary for 4.1.1.90 extracted from
- Vitamin K-dependent oxygenase/carboxylase; differential inactivation by sulfhydryl reagents (1987), Biochem. Biophys. Res. Commun., 148, 184-191.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| iodoacetic acid | poor inhibitor | Rattus norvegicus |  |
| N-ethylmaleimide | preincubation with vitamin K hydroquinone prevents NEM inhibition of epoxide formation but not of carboxylation | Rattus norvegicus | |
| p-hydroxymercuribenzoate | 1 mM, more than 90% inhibition, inhibition is reversed by dithiothreitol | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | O88496 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | separate active sites are required to support vitamin K-dependent epoxide formation and carboxylation. The binding site for vitamin K oxygenase contains an active thiol group | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutamate carboxylase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| vitamin K | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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