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Literature summary for 4.1.1.9 extracted from

  • Hunaiti, A.R.; Kolattukudy, P.E.
    Malonyl-CoA decarboxylase from Streptomyces erythreus: purification, properties, and possible role in the production of erythromycin (1984), Arch. Biochem. Biophys., 229, 426-439.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetyl-CoA
-
Saccharopolyspora erythraea
butyryl-CoA
-
Saccharopolyspora erythraea
CoA
-
Saccharopolyspora erythraea
methylmalonyl-CoA
-
Saccharopolyspora erythraea
additional information high ionic strength inhibits Saccharopolyspora erythraea
NEM no inhibition Saccharopolyspora erythraea
p-hydroxymercuribenzoate insensitive Saccharopolyspora erythraea
propionyl-CoA
-
Saccharopolyspora erythraea
SO42- reversible Saccharopolyspora erythraea
succinyl-CoA
-
Saccharopolyspora erythraea

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.143
-
malonyl-CoA
-
Saccharopolyspora erythraea

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
2 * 45000, SDS-PAGE Saccharopolyspora erythraea
93000
-
gel filtration Saccharopolyspora erythraea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Malonyl-CoA Saccharopolyspora erythraea the increase and decrease in the decarboxylase correlates with the rate of production of erythromycin, suggesting a possible role for this enzyme in the antibiotic production ?
-
?

Organism

Organism UniProt Comment Textmining
Saccharopolyspora erythraea
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.6
-
-
Saccharopolyspora erythraea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Malonyl-CoA
-
Saccharopolyspora erythraea Acetyl-CoA + CO2
-
?
Malonyl-CoA the increase and decrease in the decarboxylase correlates with the rate of production of erythromycin, suggesting a possible role for this enzyme in the antibiotic production Saccharopolyspora erythraea ?
-
?
methylmalonyl-CoA the (R)-isomer is decarboxylated at 3% of the rate observed with malonyl-CoA, the (S)-isomer is not a substrate Saccharopolyspora erythraea propionyl-CoA + CO2
-
?

Subunits

Subunits Comment Organism
dimer 2 * 45000, SDS-PAGE Saccharopolyspora erythraea

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
Saccharopolyspora erythraea

pH Range

pH Minimum pH Maximum Comment Organism
3.2 8.2 about 30% of maximal activity at pH 3.2 and pH 8.2 Saccharopolyspora erythraea