Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Saccharopolyspora erythraea | |
butyryl-CoA | - |
Saccharopolyspora erythraea | |
CoA | - |
Saccharopolyspora erythraea | |
methylmalonyl-CoA | - |
Saccharopolyspora erythraea | |
additional information | high ionic strength inhibits | Saccharopolyspora erythraea | |
NEM | no inhibition | Saccharopolyspora erythraea | |
p-hydroxymercuribenzoate | insensitive | Saccharopolyspora erythraea | |
propionyl-CoA | - |
Saccharopolyspora erythraea | |
SO42- | reversible | Saccharopolyspora erythraea | |
succinyl-CoA | - |
Saccharopolyspora erythraea |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.143 | - |
malonyl-CoA | - |
Saccharopolyspora erythraea |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
2 * 45000, SDS-PAGE | Saccharopolyspora erythraea |
93000 | - |
gel filtration | Saccharopolyspora erythraea |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Malonyl-CoA | Saccharopolyspora erythraea | the increase and decrease in the decarboxylase correlates with the rate of production of erythromycin, suggesting a possible role for this enzyme in the antibiotic production | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharopolyspora erythraea | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.6 | - |
- |
Saccharopolyspora erythraea |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Malonyl-CoA | - |
Saccharopolyspora erythraea | Acetyl-CoA + CO2 | - |
? | |
Malonyl-CoA | the increase and decrease in the decarboxylase correlates with the rate of production of erythromycin, suggesting a possible role for this enzyme in the antibiotic production | Saccharopolyspora erythraea | ? | - |
? | |
methylmalonyl-CoA | the (R)-isomer is decarboxylated at 3% of the rate observed with malonyl-CoA, the (S)-isomer is not a substrate | Saccharopolyspora erythraea | propionyl-CoA + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 45000, SDS-PAGE | Saccharopolyspora erythraea |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | - |
- |
Saccharopolyspora erythraea |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
3.2 | 8.2 | about 30% of maximal activity at pH 3.2 and pH 8.2 | Saccharopolyspora erythraea |