Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | stimulates | Euglena gracilis | |
DTT | stimulates | Euglena gracilis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxoglutarate | above 2 mM substrate inhibition | Euglena gracilis | |
Cu2+ | - |
Euglena gracilis | |
Hg2+ | - |
Euglena gracilis | |
NEM | - |
Euglena gracilis | |
Ni2+ | - |
Euglena gracilis | |
PCMB | - |
Euglena gracilis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.33 | - |
2-oxoglutarate | pH 7.0, 30°C | Euglena gracilis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | exclusively | Euglena gracilis | 5739 | - |
additional information | not: cytosol, microsomes | Euglena gracilis | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | can partially replace Mg2+ in activation | Euglena gracilis | |
Co2+ | can partially replace Mg2+ in activation | Euglena gracilis | |
MgCl2 | required | Euglena gracilis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Euglena gracilis | the enzyme has a physiologically important role coupling with succinate-semialdehyde dehydrogenase in the tricarboxylic acid cycle | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Euglena gracilis | - |
lacking a 2-oxoglutarate dehydrogenase complex (EC 1.2.4.2 + EC 2.3.1.61 + EC 1.8.1.4) | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate | highly specific | Euglena gracilis | succinate semialdehyde + CO2 | - |
? | |
additional information | the enzyme has a physiologically important role coupling with succinate-semialdehyde dehydrogenase in the tricarboxylic acid cycle | Euglena gracilis | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
- |
Euglena gracilis |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
35 | 40 | 35-40°C: activity maximum, maximum activity is maintained up to 60°C | Euglena gracilis |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
70 | - |
complete loss of activity at 70°C | Euglena gracilis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Euglena gracilis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | stimulates | Euglena gracilis | |
thiamine diphosphate | required | Euglena gracilis | |
thiamine diphosphate | Km: 0.056 mM | Euglena gracilis |