Literature summary for 4.1.1.65 extracted from

Farine, L.; Jelk, J.; Choi, J.Y.; Voelker, D.R.; Nunes, J.; Smith, T.K.; Buetikofer, P.
Phosphatidylserine synthase 2 and phosphatidylserine decarboxylase are essential for aminophospholipid synthesis in Trypanosoma brucei (2017), Mol. Microbiol., 104, 412-427 .

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Protein Variants

Protein Variants	Comment	Organism
S318A	mutation in putative cleavage motif, inhibits processing of the proenzyme. Mutant corrextly localizes to the mitochondrion	Trypanosoma brucei

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Trypanosoma brucei	5739	-

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma brucei	Q38DZ5	-	-
Trypanosoma brucei 927/4 GUTat10.1	Q38DZ5	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	presence of a putative proteolytic PSD cleavage recognition motif, WGSS, amino acids 316-319	Trypanosoma brucei

Synonyms

Synonyms	Comment	Organism
Tb927.9.10080	-	Trypanosoma brucei

General Information

General Information	Comment	Organism
physiological function	after 4 days of gene silencing, procyclic forms of Trypanosoma brucei show a growth defect compared to control parasites, while growth of PSD-depleted bloodstream forms is only slightly affected. In both life cycle forms, down-regulation of TbPSD leads to mitochondrial fragmentation and a decrease in ATP production via oxidative phosphorylation of more than 75% in PSD-depleted mitochondria	Trypanosoma brucei

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Release 2023.1 (January 2023)