Literature summary for 4.1.1.65 extracted from

Onguka, O.; Calzada, E.; Ogunbona, O.B.; Claypool, S.M.
Phosphatidylserine decarboxylase 1 autocatalysis and function does not require a mitochondrial-specific factor (2015), J. Biol. Chem., 290, 12744-12752 .

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Protein Variants

Protein Variants	Comment	Organism
G462A	mutation in the conserved LGST motif, mutant retains some, albeit reduced, phosphatidylserine decarboxylase activity	Saccharomyces cerevisiae
L461A	mutation in the conserved LGST motif, mutant retains some, albeit reduced, phosphatidylserine decarboxylase activity	Saccharomyces cerevisiae
S463A	mutation of the conserved serine residue, completely abolishes decarboxylase activity	Saccharomyces cerevisiae
T464I	mutation in the conserved LGST motif, mutant retains some, albeit reduced, phosphatidylserine decarboxylase activity	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	autocatalytic processing in the mitochondrion	Saccharomyces cerevisiae	5739	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P39006	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	a conserved LGST motif separates the enzyme into alpha- and beta-subunits. Only the serine residue of the motif is absolutely required for Psd1 autocatalysis and function. Yeast Psd1 does not require its substrate phosphatidylserine for autocatalysis. Yeast Psd1 autocatalysis does not require mitochondrion-specific phospholipids, proteins, or cofactors	Saccharomyces cerevisiae

Synonyms

Synonyms	Comment	Organism
PSD1	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)