Literature summary for 4.1.1.65 extracted from

Khandelwal, N.; Sarkar, P.; Gaur, N.; Chattopadhyay, A.; Prasad, R.
Phosphatidylserine decarboxylase governs plasma membrane fluidity and impacts drug susceptibilities of Candida albicans cells (2018), Biochim. Biophys. Acta, 1860, 2308-2319 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	Q5ABC5	-	-
Candida albicans	Q5AK66	-	-
Candida albicans ATCC MYA-2876	Q5ABC5	-	-
Candida albicans ATCC MYA-2876	Q5AK66	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
PSD1	-	Candida albicans
PSD2	-	Candida albicans

General Information

General Information	Comment	Organism
physiological function	the plasma membrane of a isoforms Psd1/Psd2 double mutant strain displays increased membrane fluidity and reduced plasma membrane dipole potential. In comparison to wild-type, the apparent phase transition temperature is reduced by about 3°C in the mutant strain. The mutant shows high diffusion of fluorescent dye rhodamine 6G and radiolabelled fluconazole, resulting in an increased drug accumulation in the mutant cells, and in an increased susceptibility to azoles	Candida albicans
physiological function	the plasma membrane of isoforms Psd1/Psd2 double mutant strain displays increased membrane fluidity and reduced plasma membrane dipole potential. In comparison to wild-type, the apparent phase transition temperature is reduced by about 3°C in the mutant strain. The mutant shows high diffusion of fluorescent dye rhodamine 6G and radiolabelled fluconazole, resulting in an increased drug accumulation in the mutant cells, and in an increased susceptibility to azoles	Candida albicans

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Release 2023.1 (January 2023)