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Literature summary for 4.1.1.65 extracted from

  • Voelker, D.R.
    Phosphatidylserine decarboxylase (1997), Biochim. Biophys. Acta, 1348, 236-244.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
pyruvate the small subunit contains a pyruvoyl prosthetic group Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mus musculus 16020
-
membrane
-
Escherichia coli 16020
-
membrane inner mitochondrial membrane and Golgi/vacuole membrane Saccharomyces cerevisiae 16020
-
mitochondrial inner membrane
-
Mus musculus 5743
-
mitochondrial inner membrane inner membrane Saccharomyces cerevisiae 5743
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidyl-L-serine Escherichia coli
-
?
-
?
phosphatidyl-L-serine Mammalia important enzyme in the synthesis of phosphatidylethanolamine ?
-
?
phosphatidyl-L-serine Homo sapiens important enzyme in the synthesis of phosphatidylethanolamine ?
-
?
phosphatidyl-L-serine Saccharomyces cerevisiae important enzyme in the synthesis of phosphatidylethanolamine ?
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Caenorhabditis elegans
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Mammalia
-
-
-
Mus musculus
-
-
-
Saccharomyces cerevisiae
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the proenzyme is sequentially processed from a size of 46000 Da to 34000 Da. Sequential removal of the mitochondrial targeting and inner membrane sorting sequence, followed by formation of the alpha and beta subunits. The final step in maturation is proposed to be cleavage and concerted prosthetic group attachment to the alpha subunit Mammalia

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Phosphatidyl-L-serine
-
Mammalia Phosphatidylethanolamine + CO2
-
?
Phosphatidyl-L-serine
-
Mus musculus Phosphatidylethanolamine + CO2
-
?
Phosphatidyl-L-serine
-
Escherichia coli Phosphatidylethanolamine + CO2
-
?
Phosphatidyl-L-serine
-
Homo sapiens Phosphatidylethanolamine + CO2
-
?
Phosphatidyl-L-serine
-
Saccharomyces cerevisiae Phosphatidylethanolamine + CO2
-
?
Phosphatidyl-L-serine
-
Arabidopsis thaliana Phosphatidylethanolamine + CO2
-
?
Phosphatidyl-L-serine
-
Caenorhabditis elegans Phosphatidylethanolamine + CO2
-
?
phosphatidyl-L-serine
-
Escherichia coli ?
-
?
phosphatidyl-L-serine important enzyme in the synthesis of phosphatidylethanolamine Mammalia ?
-
?
phosphatidyl-L-serine important enzyme in the synthesis of phosphatidylethanolamine Homo sapiens ?
-
?
phosphatidyl-L-serine important enzyme in the synthesis of phosphatidylethanolamine Saccharomyces cerevisiae ?
-
?