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Literature summary for 4.1.1.64 extracted from

  • Liu, W.; Toney, M.D.
    Kinetic and thermodynamic analysis of the interaction of cations with dialkylglycine decarboxylase (2004), Biochemistry, 43, 4998-5010.
    View publication on PubMed
Search for more literature for 4.1.1.64

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2
-
 2-aminoisobutanoate activated by K+ Burkholderia cepacia
2.2
-
 2-aminoisobutanoate activated by Rb+ Burkholderia cepacia
4.4
-
 2-aminoisobutanoate activated by NH4+ Burkholderia cepacia
5.8
-
 2-aminoisobutanoate activated by Mg2+ Burkholderia cepacia
6.6
-
 2-aminoisobutanoate activated by Tl+ Burkholderia cepacia
7.3
-
 2-aminoisobutanoate activated by Cs+ Burkholderia cepacia
11
-
 2-aminoisobutanoate activated by Li+ Burkholderia cepacia
13
-
 2-aminoisobutanoate activated by Na+ Burkholderia cepacia
18
-
 2-aminoisobutanoate activated by Ca2+ Burkholderia cepacia
66
-
 2-aminoisobutanoate activated by Ba2+ Burkholderia cepacia

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ gives 10fold lower activity compared to monovalent alkali cations of similar ionic radius, increases association of pyridoxal 5'-phosphate and decreases dissociation rate constant of pyridoxal 5'-phosphate Burkholderia cepacia
Ca2+ gives 10fold lower activity compared to monovalent alkali cations of similar ionic radius Burkholderia cepacia
Cs+ activates to a lesser extent than K+ Burkholderia cepacia
K+ activity is dependent on cations. K+ is the monovalent cation with the optimal size for catalytic activity, increases association of pyridoxal 5'-phosphate and decreases dissociation rate constant of pyridoxal 5'-phosphate Burkholderia cepacia
Li+ activates to a lesser extent than K+ Burkholderia cepacia
Mg2+ gives 10fold lower activity compared to monovalent alkali cations of similar ionic radius Burkholderia cepacia
Na+ activates to a lesser extent than K+, increases association of pyridoxal 5'-phosphate and decreases dissociation rate constant of pyridoxal 5'-phosphate Burkholderia cepacia
NH4+ activates to a lesser extent than K+ Burkholderia cepacia
Rb+ activates to a lesser extent than K+ Burkholderia cepacia
Tl+ activates to a lesser extent than K+ Burkholderia cepacia

Organism

Organism UniProt Comment Textmining
Burkholderia cepacia
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-Aminoisobutanoate + pyruvate
-
 Burkholderia cepacia L-Ala + acetone + CO2
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.05
-
 2-aminoisobutanoate activated by Ca2+ Burkholderia cepacia
0.076
-
 2-aminoisobutanoate activated by Mg2+ Burkholderia cepacia
0.86
-
 2-aminoisobutanoate activated by Li+ Burkholderia cepacia
1.4
-
 2-aminoisobutanoate activated by Ba2+ Burkholderia cepacia
1.83
-
 2-aminoisobutanoate activated by Na+ Burkholderia cepacia
3.8
-
 2-aminoisobutanoate activated by Cs+ Burkholderia cepacia
4.9
-
 2-aminoisobutanoate activated by NH4+ Burkholderia cepacia
5.22
-
 2-aminoisobutanoate activated by Tl+ Burkholderia cepacia
7.4
-
 2-aminoisobutanoate activated by Rb+ Burkholderia cepacia
10.4
-
 2-aminoisobutanoate activated by K+ Burkholderia cepacia

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent on Burkholderia cepacia