Literature summary for 4.1.1.64 extracted from

Malashkevich, V.N.; Strop, P.; Keller, J.W.; Jansonius, J.N.; Toney, M.D.
Crystal structures of dialkylglycine decarboxylase inhibitor complexes (1999), J. Mol. Biol., 294, 193-200.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with four inhibitors	Burkholderia cepacia

Inhibitors

Inhibitors	Comment	Organism	Structure
1-amino-1-cyclopropane carboxylate	i.e. ACC	Burkholderia cepacia
5'-phosphopyridoxyl-2-methylalanine	i.e. PPL-MeAla	Burkholderia cepacia
D-cycloserine	competitive, L-isomer has 3000fold greater inhibitory potency than D-isomer	Burkholderia cepacia
L-Cycloserine	competitive, L-isomer has 3000fold greater inhibitory potency than D-isomer	Burkholderia cepacia
phosphono-2-methylalanine	-	Burkholderia cepacia

Organism

Organism	UniProt	Comment	Textmining
Burkholderia cepacia	P16932	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine	mechanism	Burkholderia cepacia	a

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Release 2023.1 (January 2023)