Literature summary for 4.1.1.64 extracted from

Zhou, X.; Toney, M.D.
pH Studies on the mechanism of the pyridoxal phosphate-dependent dialkylglycine decarboxylase (1999), Biochemistry, 38, 311-320.

Search for more literature for 4.1.1.64

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	not inhibitory: pyruvate	Burkholderia cepacia

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.098	-	pyruvate	pH 7.5	Burkholderia cepacia
2.2	-	2-aminoisobutyrate	pH 7.5	Burkholderia cepacia

Organism

Organism	UniProt	Comment	Textmining
Burkholderia cepacia	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine	mechanism	Burkholderia cepacia	a
2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine	pH-studies on the mechanism	Burkholderia cepacia	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-aminoisobutyrate + pyruvate	-	Burkholderia cepacia	L-Ala + acetone + CO2	-	?
Pyruvate + 2-aminoisobutanoate	-	Burkholderia cepacia	?	-	?

pH Range

pH Minimum	pH Maximum	Comment	Organism
additional information	-	pH-dependence of transamination half-reaction	Burkholderia cepacia

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	dependent on	Burkholderia cepacia

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Release 2023.1 (January 2023)