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Literature summary for 4.1.1.64 extracted from

  • Zhou, X.; Kay, S.; Toney, M.D.
    Coexisting kinetically distinguishable forms of dialkylglycine decarboxylase engendered by alkali metal ions (1998), Biochemistry, 37, 5761-5769.
    View publication on PubMed
Search for more literature for 4.1.1.64

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Burkholderia cepacia

Inhibitors

Inhibitors Comment Organism Structure
1-aminocyclopropane 1-carboxylate
-
 Burkholderia cepacia
Li+
-
 Burkholderia cepacia
Na+
-
 Burkholderia cepacia

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.12
-
 2-aminoisobutanoate enzyme with Na+ in the metal binding site Burkholderia cepacia
2
-
 2-aminoisobutanoate enzyme with K+ in the metal binding site Burkholderia cepacia
8.7
-
 2-aminoisobutanoate enzyme with Na+ in the metal binding site Burkholderia cepacia

Metals/Ions

Metals/Ions Comment Organism Structure
K+ activates Burkholderia cepacia
K+ the K+-activated enzyme in solution exists in two conformations differing in catalytic competence Burkholderia cepacia
additional information hysteretic enzyme whose conformational distribution is controlled by the identity of the alkali metal ion bound near the active site Burkholderia cepacia
Rb+ activates Burkholderia cepacia

Organism

Organism UniProt Comment Textmining
Burkholderia cepacia
-
-
-

Reaction

Reaction Comment Organism Reaction ID
2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine cooperativity does not play a role in catalysis or regulation Burkholderia cepacia
a

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.29
-
 2-aminoisobutanoate enzyme with Na+ in the metal binding site Burkholderia cepacia
4.47
-
 2-aminoisobutanoate enzyme with Rb+ in the metal binding site Burkholderia cepacia
13.1
-
 2-aminoisobutanoate enzyme with K+ in the metal binding site Burkholderia cepacia

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent on Burkholderia cepacia