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Literature summary for 4.1.1.6 extracted from

  • Kim, J.; Seo, H.M.; Bhatia, S.K.; Song, H.S.; Kim, J.H.; Jeon, J.M.; Choi, K.Y.; Kim, W.; Yoon, J.J.; Kim, Y.G.; Yang, Y.H.
    Production of itaconate by whole-cell bioconversion of citrate mediated by expression of multiple cis-aconitate decarboxylase (cadA) genes in Escherichia coli (2017), Sci. Rep., 7, 39768 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Tween 80 Tween 80 at a concentration of 0.1% resulted in a slight (7%) increase in conversion activity Aspergillus terreus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Aspergillus terreus

Inhibitors

Inhibitors Comment Organism Structure
Fe2+
-
Aspergillus terreus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cis-aconitate Aspergillus terreus
-
itaconate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus terreus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cis-aconitate
-
Aspergillus terreus itaconate + CO2
-
?

Synonyms

Synonyms Comment Organism
CadA
-
Aspergillus terreus
cis-aconitate decarboxylase
-
Aspergillus terreus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
-
Aspergillus terreus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 40 more than 60% activity at 25 and 40°C, about 90% activity at 30°C Aspergillus terreus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
-
Aspergillus terreus

pH Range

pH Minimum pH Maximum Comment Organism
5 8 about 20% activity at pH 5.0, 100% activity at pH 5.5, about 65% activity at pH 6.0, about 50% activity at pH 6.5, about 35% activity at pH 7.0, about 25% activity at pH 7.5, about 20% activity at pH 8.0 Aspergillus terreus