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Literature summary for 4.1.1.52 extracted from
- 6-Methylsalicylic acid (2,6-cresotic acid) decarboxylase (1975), Methods Enzymol., 43, 530-540.
General Stability
| General Stability | Organism |
|---|---|
| unstable in solutions of low ionic strength | Penicillium griseofulvum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Hydroxy-1-naphthoic acid | - |
Penicillium griseofulvum |  |
| 2-Methylbenzoic acid | - |
Penicillium griseofulvum | |
| 3-methylsalicylic acid | - |
Penicillium griseofulvum | |
| 4-methylsalicylic acid | - |
Penicillium griseofulvum | |
| 6-Methylanthranilic acid | - |
Penicillium griseofulvum | |
| 6-Methylsalicylic acid | - |
Penicillium griseofulvum | |
| diethyl dicarbonate | 10 mM, complete inhibition | Penicillium griseofulvum | |
| NaNO3 | 10 mM, 20% inhibition | Penicillium griseofulvum | |
| Rose bengal | photooxidation | Penicillium griseofulvum | |
| salicylic acid | - |
Penicillium griseofulvum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
6-Ethylsalicylic acid | 6-methylsalicylic acid | Penicillium griseofulvum | |
| 0.04 | - |
Homoorsellinic acid | - |
Penicillium griseofulvum | |
| 0.1 | - |
orsellinic acid | - |
Penicillium griseofulvum | |
| 0.15 | - |
3-bromoorsellinic acid | - |
Penicillium griseofulvum | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 56000 | 60000 | gel filtration, sucrose density gradient sedimentation | Penicillium griseofulvum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-Methylsalicylate | Penicillium griseofulvum | enzyme catalyzes the first step in the conversion of 6-methylsalicylic acid into patulin | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Penicillium griseofulvum | - |
- |
- |
Oxidation Stability
| Oxidation Stability | Organism |
|---|---|
| photooxidation in presence of rose Bengal is prevented in presence of substrate or 2-hydroxy-6-methylsalicylic acid | Penicillium griseofulvum |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 11.6 | - |
- |
Penicillium griseofulvum |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -15°C, pH 7.5, 50% glycerol, 5% w/v (NH4)2SO4, stable for several months | Penicillium griseofulvum |
| -25°C, pH 7.5, without glycerol, stable for at least 1 year | Penicillium griseofulvum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-Bromoorsellinic acid | at 6% the activity with 6-methylsalicylic acid | Penicillium griseofulvum | 1,3-Dihydroxy-2-bromo-5-methylbenzene + CO2 | - |
? | |
| 6-Ethylsalicylic acid | at 100% of the activity with 6-methylsalicylic acid | Penicillium griseofulvum | 3-Ethyl-1-hydroxybenzene + CO2 | - |
? | |
| 6-Methylsalicylate | enzyme catalyzes the first step in the conversion of 6-methylsalicylic acid into patulin | Penicillium griseofulvum | ? | - |
? | |
| 6-Methylsalicylic acid | - |
Penicillium griseofulvum | 3-Cresol + CO2 | - |
? | |
| Homoorsellinic acid | at 100% of the activity with 6-methylsalicylic acid | Penicillium griseofulvum | ? | - |
? | |
| Orsellinic acid | at 80% of the activity with 6-methylsalicylic acid | Penicillium griseofulvum | 1,3-Dihydroxy-5-methylbenzene + CO2 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 7.5 | - |
Penicillium griseofulvum |
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