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Literature summary for 4.1.1.50 extracted from

  • McCloskey, D.E.; Bale, S.; Secrist, J.A.; Tiwari, A.; Moss, T.H.; Valiyaveettil, J.; Brooks, W.H.; Guida, W.C.; Pegg, A.E.; Ealick, S.E.
    New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: Studies of adenine C8 substitution in structural analogues of S-adenosylmethionine (2009), J. Med. Chem., 52, 1388-1407.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.50

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) JM109 cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
AdoMetDC F223A mutant complexed with S-adenosylmethionine and the wild type protein complexed with several substituted inhibitors, hanging drop vapor diffusion method, at 22°C in 13-16% PEG 8000, 100 mM Tris, pH 8.0-9.0, and 10 mM dithiothreitol Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-amidinoindan-1-one-2'-amidinohydrazone CGP48664A Homo sapiens
5'-deoxy 5'-[(2-guanidinoethyl)methylamino]adenosine less than 5% inhibition at 0.1 mM Homo sapiens
5'-deoxy-5'-(2-methylaminoethylamino)adenosine less than 5% inhibition at 0.1 mM Homo sapiens
5'-deoxy-5'-(3-methylaminopropylamino)-8-phenyladenosine sulfate less than 5% inhibition at 0.1 mM Homo sapiens
5'-deoxy-5'-(N,N-dimethylamino)-8-methyladenosine
-
 Homo sapiens
5'-deoxy-5'-(N,N-dimethylamino)adenosine
-
 Homo sapiens
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine chloride
-
 Homo sapiens
5'-deoxy-5'-dimethylsulfonioadenosine chloride
-
 Homo sapiens
5'-deoxy-5'-[(2-hydrazinocarbonylethyl)methylamino]-8-methyladenosine sulfate
-
 Homo sapiens
5'-deoxy-5'-[(2-hydrazinocarbonylethyl)methylamino]-adenosine sulfate
-
 Homo sapiens
5'-deoxy-5'-[(2-hydrazinoethyl)methylamino]adenosine
-
 Homo sapiens
5'-deoxy-5'-[(2-hydroxyamidinoethyl)methylamino]adenosine
-
 Homo sapiens
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
 Homo sapiens
5'-deoxy-5'-[(hydrazinocarbonylmethyl)methylamino]-8-methyladenosine
-
 Homo sapiens
5'-deoxy-8-(methylamino)-5'-(3-methylaminopropylamino)adenosine sulfate less than 5% inhibition at 0.1 mM Homo sapiens
5'-deoxy-8-methyl-5'-(2-methylaminoethylamino)adenosine less than 5% inhibition at 0.1 mM Homo sapiens
5'-[(2-aminoethyl)methylamino]-5'-deoxy-8-methyladenosine
-
 Homo sapiens
5'-[(2-aminoethyl)methylamino]-5'-deoxyadenosine less than 5% inhibition at 0.1 mM Homo sapiens
5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
-
 Homo sapiens
5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
-
 Homo sapiens
5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-phenyladenosine sulfate less than 5% inhibition at 0.1 mM Homo sapiens
5'-[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine
-
 Homo sapiens
5'-[(2-carboxamidoethyl)methyamino]-5'-deoxy-8-ethyladenosine sulfate
-
 Homo sapiens
5'-[(2-carboxamidoethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
-
 Homo sapiens
5'-[(2-carboxamidoethyl)methylamino]-5'-deoxyadenosine sulfate
-
 Homo sapiens
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
-
 Homo sapiens
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-ethyladenosine sulfate
-
 Homo sapiens
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
-
 Homo sapiens
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-phenyladenosine sulfate less than 5% inhibition at 0.1 mM Homo sapiens
5'-[(3-aminopropyl)methylamino]-5'-deoxyadenosine sulfate
-
 Homo sapiens
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
-
 Homo sapiens
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-ethyladenosine sulfate
-
 Homo sapiens
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
-
 Homo sapiens
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-oxoadenosine sulfate
-
 Homo sapiens
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-phenyladenosine sulfate less than 5% inhibition at 0.1 mM Homo sapiens
5'-[(4-aminooxybutyl)methylamino]-5'-deoxyadenosine sulfate
-
 Homo sapiens
5'-[(carboxamidomethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate less than 5% inhibition at 0.1 mM Homo sapiens
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
-
 Homo sapiens
methylglyoxal bis(guanylhydrazone) competitive inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P17707 proenzyme
-

Purification (Commentary)

Purification (Comment) Organism
Talon metal affinity resin column chromatography and Sephadex G-75 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine
-
 Homo sapiens (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?

Synonyms

Synonyms Comment Organism
AdoMetDC
-
 Homo sapiens
S-Adenosylmethionine decarboxylase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000005
-
-
 Homo sapiens 5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
0.000007
-
-
 Homo sapiens 5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
0.000011
-
-
 Homo sapiens 5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-oxoadenosine sulfate
0.000015
-
-
 Homo sapiens 5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-ethyladenosine sulfate
0.000018
-
-
 Homo sapiens 5'-[(4-aminooxybutyl)methylamino]-5'-deoxyadenosine sulfate
0.000049
-
-
 Homo sapiens 5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
0.000055
-
-
 Homo sapiens 5'-[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine
0.000086
-
-
 Homo sapiens 5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
0.00017
-
-
 Homo sapiens 5'-deoxy-5'-[(2-hydrazinocarbonylethyl)methylamino]-8-methyladenosine
0.0004
-
-
 Homo sapiens 5'-[(2-carboxamidoethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
0.0006
-
-
 Homo sapiens 5'-deoxy-5'-(N,N-dimethylamino)-8-methyladenosine
0.0015
-
-
 Homo sapiens 5'-deoxy-5'-[(2-hydrazinocarbonylethyl)methylamino]-adenosine sulfate
0.003
-
-
 Homo sapiens 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine chloride
0.004
-
-
 Homo sapiens 5'-[(2-carboxamidoethyl)methyamino]-5'-deoxy-8-ethyladenosine sulfate
0.007
-
-
 Homo sapiens 5'-[(2-carboxamidoethyl)methylamino]-5'-deoxyadenosine sulfate
0.009
-
-
 Homo sapiens 5'-deoxy-5'-(N,N-dimethylamino)adenosine
0.015
-
-
 Homo sapiens 5'-deoxy-5'-dimethylsulfonioadenosine chloride
0.031
-
-
 Homo sapiens 5'-deoxy-5'-[(hydrazinocarbonylmethyl)methylamino]-8-methyladenosine
0.07
-
-
 Homo sapiens 5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
0.088
-
-
 Homo sapiens 5'-[(2-aminoethyl)methylamino]-5'-deoxy-8-methyladenosine
0.157
-
-
 Homo sapiens 5'-deoxy-5'-[(2-hydroxyamidinoethyl)methylamino]adenosine
0.42
-
-
 Homo sapiens 5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-ethyladenosine sulfate
0.44
-
-
 Homo sapiens 5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
0.5
-
-
 Homo sapiens 5'-[(3-aminopropyl)methylamino]-5'-deoxyadenosine sulfate