Literature summary for 4.1.1.50 extracted from

Bacchi, C.J.; Barker, R.H.; Rodriguez, A.; Hirth, B.; Rattendi, D.; Yarlett, N.; Hendrick, C.L.; Sybertz, E.
Trypanocidal activity of 8-methyl-5-[[(Z)-4-aminobut-2-enyl]-(methylamino)]adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor (2009), Antimicrob. Agents Chemother., 53, 3269-3272.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5'-[[(Z)-4-aminobut-2-enyl](methylamino)]adenosine	MDL-73811	Trypanosoma brucei brucei
5'-[[(Z)-4-aminobut-2-enyl](methylamino)]adenosine	MDL-73811	Trypanosoma brucei rhodesiense
8-methyl-5'-[[(Z)-4-aminobut-2-enyl]-(methylamino)]adenosine	Genz-644131, potent inhibitor	Trypanosoma brucei brucei
8-methyl-5'-[[(Z)-4-aminobut-2-enyl]-(methylamino)]adenosine	Genz-644131, potent inhibitor	Trypanosoma brucei rhodesiense

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma brucei brucei	-	-	-
Trypanosoma brucei brucei Lab 110 EATRO	-	-	-
Trypanosoma brucei rhodesiense	-	strains KETRI 243 and 2538	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine	-	Trypanosoma brucei brucei	(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2	-	?
S-adenosyl-L-methionine	-	Trypanosoma brucei rhodesiense	(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2	-	?
S-adenosyl-L-methionine	-	Trypanosoma brucei brucei Lab 110 EATRO	(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2	-	?

Subunits

Subunits	Comment	Organism
heterodimer	-	Trypanosoma brucei brucei
heterodimer	-	Trypanosoma brucei rhodesiense

Synonyms

Synonyms	Comment	Organism
AdoMetDC	-	Trypanosoma brucei brucei
AdoMetDC	-	Trypanosoma brucei rhodesiense
S-Adenosylmethionine decarboxylase	-	Trypanosoma brucei brucei
S-Adenosylmethionine decarboxylase	-	Trypanosoma brucei rhodesiense

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Trypanosoma brucei brucei
pyridoxal 5'-phosphate	-	Trypanosoma brucei rhodesiense

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Release 2023.1 (January 2023)