Literature summary for 4.1.1.50 extracted from

Brooks, W.H.; McCloskey, D.E.; Daniel, K.G.; Ealick, S.E.; Secrist, J.A.; Waud, W.R.; Pegg, A.E.; Guida, W.C.
In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase (2007), J. Chem. Inf. Model., 47, 1897-1905.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
(1E)-1-(9-bromo-3-phenanthryl)ethanone oxime	75% inhibition at 0.1 mM	Homo sapiens
1,3-di-9H-fluoren-2-ylthiourea	69% inhibition at 0.1 mM	Homo sapiens
1-(4-hydroxy-5-isopropyl-2-methylphenyl)-3-(1-naphthyl)urea	61% inhibition at 0.1 mM	Homo sapiens
2'-[(9H-fluoren-2-ylamino)carbonyl]biphenyl-2-carboxylate	74% inhibition at 0.1 mM	Homo sapiens
2-[2-(diethylammonio)ethyl]-9-hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-2-ium	67% inhibition at 0.1 mM	Homo sapiens
4-[(E)-2-(2-chlorophenyl)vinyl]quinolinium	67% inhibition at 0.1 mM	Homo sapiens
9-amino-6-[(E)-(2,6-diaminopyridin-3-yl)diazenyl]-2-ethoxyacridinium	64% inhibition at 0.1 mM	Homo sapiens
9-hydroxy-5,11-dimethyl-2-(2-piperidinium-1-ylethyl)-6H-pyrido[4,3-b]carbazol-2-ium	69% inhibition at 0.1 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P17707	-	-

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Release 2023.1 (January 2023)